Mike Kent1, Greg Brooker1, Ryan Fisher1, Geraldine Goh1, Ranieri Falcao Aguiar2, John Papadimitriou3, Daniel Wong4, Richard Carey-Smith1, Anne Cowie1. 1. PlusLife, Perth Orthopaedic Institute, Perth 6009, Western Australia, Australia. 2. Department of Radiology, Sir Charles Gairdner Hospital, Perth 6009, Western Australia Australia. 3. PlusLife, Perth Orthopaedic Institute, Perth 6009, Western Australia, Australia; PathWest, Sir Charles Gairdner Hospital, Perth 6009, Western Australia Australia. 4. PathWest, Sir Charles Gairdner Hospital, Perth 6009, Western Australia Australia.
Abstract
OBJECTIVE: Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis. METHODS: 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. RESULTS: CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. CONCLUSIONS: Apparent lesions were not pathological. PRACTICE IMPLICATIONS: Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.
OBJECTIVE: Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis. METHODS: 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded. RESULTS: CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process. CONCLUSIONS: Apparent lesions were not pathological. PRACTICE IMPLICATIONS: Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.
Entities:
Keywords:
Bone and tissue banking; Long bone allografts; Lytic lesions; Quality control; Tumour reconstruction
Authors: H Chandler; J Clark; S Murphy; J McCarthy; B Penenberg; K Danylchuk; B Roehr Journal: Clin Orthop Relat Res Date: 1994-01 Impact factor: 4.176