Stephen T Joy1, Paramjit S Arora1. 1. Department of Chemistry, New York University, New York, NY 10003, USA. arora@nyu.edu.
Abstract
Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.
Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond cannucleate and stabilize the α-helical conformation inn class="Chemical">peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.
Authors: Brooke Bullock Lao; Ivan Grishagin; Hanah Mesallati; Thomas F Brewer; Bogdan Z Olenyuk; Paramjit S Arora Journal: Proc Natl Acad Sci U S A Date: 2014-05-12 Impact factor: 11.205
Authors: Christopher H Douse; Sabrina J Maas; Jemima C Thomas; James A Garnett; Yunyun Sun; Ernesto Cota; Edward W Tate Journal: ACS Chem Biol Date: 2014-08-06 Impact factor: 5.100
Authors: Effrat L Fayer; William M Gilliland; J Michael Ramsey; Nancy L Allbritton; Marcey L Waters Journal: Chem Commun (Camb) Date: 2017-12-21 Impact factor: 6.222