Literature DB >> 27045201

Perioperative circulating tumor cell detection: Current perspectives.

Jussuf T Kaifi1,2, Guangfu Li1,3, Gary Clawson4, Eric T Kimchi1,2,3, Kevin F Staveley-O'Carroll1,2,3.   

Abstract

Primary cancer resections and in selected cases surgical metastasectomies significantly improve survival, however many patients develop recurrences. Circulating tumor cells (CTCs) function as an independent marker that could be used in the prognostication of different cancers. Sampling of blood and bone marrow compartments during cancer resections is a unique opportunity to increase individual tumor cell capture efficiency. This review will address the diagnostic and therapeutic potentials of perioperative tumor isolation and highlight the focus of future studies on characterization of single disseminated cancer cells to identify targets for molecular therapy and immune escape mechanisms.

Entities:  

Keywords:  Circulating tumor cells; disseminated tumor cells; metastasectomy; surgery

Mesh:

Year:  2016        PMID: 27045201      PMCID: PMC5004694          DOI: 10.1080/15384047.2016.1167296

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN: 1538-4047            Impact factor:   4.742


  115 in total

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Authors:  Gary A Clawson
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5.  Detection and characterization of carcinoma cells in the blood.

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6.  Immunocytochemical detection of isolated tumour cells in bone marrow of patients with untreated stage C prostatic cancer.

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3.  Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma.

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5.  Colorectal Cancer Stem Cells Fuse with Monocytes to Form Tumour Hybrid Cells with the Ability to Migrate and Evade the Immune System.

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Review 6.  Tumor-Cell-Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer.

Authors:  Yariswamy Manjunath; David Porciani; Jonathan B Mitchem; Kanve N Suvilesh; Diego M Avella; Eric T Kimchi; Kevin F Staveley-O'Carroll; Donald H Burke; Guangfu Li; Jussuf T Kaifi
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7.  Preoperative circulating tumor cells to predict microvascular invasion and dynamical detection indicate the prognosis of hepatocellular carcinoma.

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  8 in total

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