| Literature DB >> 27045201 |
Jussuf T Kaifi1,2, Guangfu Li1,3, Gary Clawson4, Eric T Kimchi1,2,3, Kevin F Staveley-O'Carroll1,2,3.
Abstract
Primary cancer resections and in selected cases surgical metastasectomies significantly improve survival, however many patients develop recurrences. Circulating tumor cells (CTCs) function as an independent marker that could be used in the prognostication of different cancers. Sampling of blood and bone marrow compartments during cancer resections is a unique opportunity to increase individual tumor cell capture efficiency. This review will address the diagnostic and therapeutic potentials of perioperative tumor isolation and highlight the focus of future studies on characterization of single disseminated cancer cells to identify targets for molecular therapy and immune escape mechanisms.Entities:
Keywords: Circulating tumor cells; disseminated tumor cells; metastasectomy; surgery
Mesh:
Year: 2016 PMID: 27045201 PMCID: PMC5004694 DOI: 10.1080/15384047.2016.1167296
Source DB: PubMed Journal: Cancer Biol Ther ISSN: 1538-4047 Impact factor: 4.742