Literature DB >> 27044721

[Arsenic - Poison or medicine?].

Karolina Kulik-Kupka1, Aneta Koszowska2, Anna Brończyk-Puzoń2, Justyna Nowak2, Katarzyna Gwizdek3, Barbara Zubelewicz-Szkodzińska2.   

Abstract

Arsenic (As) is commonly known as a poison. Only a few people know that As has also been widely used in medicine. In the past years As and its compounds were used as a medicine for the treatment of such diseases as diabetes, psoriasis, syphilis, skin ulcers and joint diseases. Nowadays As is also used especially in the treatment of patients with acute promyelocytic leukemia. The International Agency for Research on Cancer (IARC) has recognized arsenic as an element with carcinogenic effect evidenced by epidemiological studies, but as previously mentioned it is also used in the treatment of neoplastic diseases. This underlines the specificity of the arsenic effects. Arsenic occurs widely in the natural environment, for example, it is present in soil and water, which contributes to its migration to food products. Long exposure to this element may lead to liver damages and also to changes in myocardium. Bearing in mind that such serious health problems can occur, monitoring of the As presence in the environmental media plays a very important role. In addition, the occupational risk of As exposure in the workplace should be identified and checked. Also the standards for As presence in food should be established. This paper presents a review of the 2015 publications based on the Medical database like PubMed and Polish Medical Bibliography. It includes the most important information about arsenic in both forms, poison and medicine. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Entities:  

Keywords:  apoptosis; arsenic; arsenic trioxide; medicine; neoplastic diseases; poison

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Year:  2016        PMID: 27044721     DOI: 10.13075/mp.5893.00322

Source DB:  PubMed          Journal:  Med Pr        ISSN: 0465-5893            Impact factor:   0.760


  5 in total

1.  Identification of Key Potential Targets and Pathway for Arsenic Trioxide by Systemic Bioinformatics Analysis in Pancreatic Cancer.

Authors:  Yanan Pang; Zhiyong Liu; Shanrong Liu
Journal:  Pathol Oncol Res       Date:  2018-11-30       Impact factor: 3.201

Review 2.  Vegetating erosive cutaneous lesions and pyogenic granuloma in the course of mucous membrane pemphigoid: a case report and review of literature.

Authors:  Beata Jakubowska; Cezary Kowalewski; Norito Ishii; Takashi Hashimoto; Katarzyna Wozniak
Journal:  Int Wound J       Date:  2018-06-29       Impact factor: 3.315

3.  Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis.

Authors:  Mohamed A Dkhil; Ahmed E Abdel Moneim; Amira A Bauomy; Mona Khalil; Esam M Al-Shaebi; Saleh Al-Quraishy
Journal:  Mol Biol Rep       Date:  2019-12-09       Impact factor: 2.316

4.  Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I.

Authors:  Sunbin Ling; Qiaonan Shan; Peng Liu; Tingting Feng; Xuanyu Zhang; Penghui Xiang; Kangchen Chen; Haiyang Xie; Penghong Song; Lin Zhou; Jimin Liu; Shusen Zheng; Xiao Xu
Journal:  Cell Death Dis       Date:  2017-11-02       Impact factor: 8.469

5.  A Case of Syphilis with High Bone Arsenic Concentration from Early Modern Cemetery (Wroclaw, Poland).

Authors:  Pawel Dabrowski; Michal Jerzy Kulus; Agata Cieslik; Zygmunt Domagala; Rafał J Wiglusz; Piotr Kuropka; Jan Kuryszko; Agata Thannhauser; Lukasz Szleszkowski; Piotr Marian Wojtulek; Daniel Solinski; Piotr Dziegiel
Journal:  Open Life Sci       Date:  2019-11-17       Impact factor: 0.938

  5 in total

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