Martin Eichler1,2,3, Judith Keszte3, Alexandra Meyer3, Helge Danker4, Orlando Guntinas-Lichius5, Jens Oeken6, Friedemann Pabst7, Susanne Singer1. 1. Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University of Mainz, Mainz, Germany. 2. German Cancer Consortium (DKTK), Heidelberg, Germany. 3. Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany. 4. Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, Germany. 5. Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany. 6. Department of Otorhinolaryngology, Hospital Chemnitz, Chemnitz, Germany. 7. Department of Otorhinolaryngology, Hospital Dresden-Friedrichstadt, Dresden, Germany.
Abstract
BACKGROUND: We examined the relation of tobacco and alcohol consumption after total laryngectomy with overall survival (OS). METHODS: Tobacco and alcohol consumption was assessed at 5 time points after total laryngectomy. Patients were followed up for survival until December 31, 2014. A multivariate Cox regression was fitted to test for differences in OS. RESULTS: Three hundred fifty-nine patients were included in this study. Compared to former smokers, never smokers had hazard ratios (HRs) of 0.88 (95% confidence intervals [CIs] = 0.50-1.59), and continuous smokers 1.31 (95% CI = 0.87-1.96). Constantly high alcohol consumption after total laryngectomy had an HR of 2.19 (95% CI = 1.30-3.67). Duration of smoking (HR = 1.00; 95% CI = 0.99-1.01) and last known status of alcohol consumption (HR = 1.00; 95% CI = 0.76-1.33) was not related to OS. CONCLUSION: Patients who smoke after total laryngectomy have a 30% higher risk of dying than people who gave up smoking, and constant high alcohol consumption is also a strong risk factor for dying.
BACKGROUND: We examined the relation of tobacco and alcohol consumption after total laryngectomy with overall survival (OS). METHODS:Tobacco and alcohol consumption was assessed at 5 time points after total laryngectomy. Patients were followed up for survival until December 31, 2014. A multivariate Cox regression was fitted to test for differences in OS. RESULTS: Three hundred fifty-nine patients were included in this study. Compared to former smokers, never smokers had hazard ratios (HRs) of 0.88 (95% confidence intervals [CIs] = 0.50-1.59), and continuous smokers 1.31 (95% CI = 0.87-1.96). Constantly high alcohol consumption after total laryngectomy had an HR of 2.19 (95% CI = 1.30-3.67). Duration of smoking (HR = 1.00; 95% CI = 0.99-1.01) and last known status of alcohol consumption (HR = 1.00; 95% CI = 0.76-1.33) was not related to OS. CONCLUSION:Patients who smoke after total laryngectomy have a 30% higher risk of dying than people who gave up smoking, and constant high alcohol consumption is also a strong risk factor for dying.
Authors: J Keszte; H Danker; A Dietz; E Meister; F Pabst; O Guntinas-Lichius; J Oeken; S Singer; A Meyer Journal: Eur Arch Otorhinolaryngol Date: 2016-10-15 Impact factor: 2.503
Authors: Saverio Caini; Marco Del Riccio; Virginia Vettori; Oriana D'Ecclesiis; Pierluigi Bonomo; Luca Giovanni Locatello; Viola Salvestrini; Oreste Gallo; Marta Tagliabue; Sara Raimondi; Calogero Saieva; Flavia Cozzolino; Benedetta Bendinelli; Sara Gandini Journal: Br J Cancer Date: 2022-08-23 Impact factor: 9.075