| Literature DB >> 27043010 |
Zhigao Zhang1, Yong Chen1, Daniel Adu-Ampratwum1, Antony Akura Okumu1, Nathaniel T Kenton1, Craig J Forsyth1.
Abstract
An efficient synthesis of the C22-C40 domain of the azaspiracids is described. The synthetic route features a Nozaki-Hiyama-Kishi (NHK) coupling and chelation controlled Mukaiyama aldol reaction to access an acyclic intermediate and a double-intramolecular-hetero-Michael addition (DIHMA) to provide the FG-ring system bridged ketal.Entities:
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Year: 2016 PMID： 27043010 DOI： 10.1021/acs.orglett.6b00557
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005