Elizabeth Mathew Iype1, Vijay Jagad2, Santhosh Kumar Nochikattil3, Bipin T Varghese1, Paul Sebastian4. 1. Additional Professor, Department of Surgical Oncology, Regional Cancer Centre , Trivandrum, Kerala, India . 2. MCh trainee, Department of Surgical Oncology, Regional Cancer Centre , Trivandrum, Kerala, India . 3. Fellow in Head and Neck Surgical Oncology, Department of Surgical Oncology, Regional Cancer Centre , Trivandrum, Kerala, India . 4. Director, Regional Cancer Centre , Trivandrum, Kerala, India .
Abstract
INTRODUCTION: Intraoperative management of thyroid gland in laryngeal and hypopharyngeal cancer is controversial. AIM: The objectives of this study were to determine the incidence of thyroid gland invasion in patients undergoing surgery for laryngeal or hypopharyngeal carcinoma, to assess predictive factors and to assess the prognosis in patients with and without thyroid gland invasion. MATERIALS AND METHODS: One hundred and thirty-three patients who underwent surgery for carcinoma larynx and hypopharynx from 2006 to 2010 were reviewed retrospectively. Surgical specimens were examined to determine the incidence of thyroid gland invasion and predictive factors were analysed. The recurrence rate and the survival in patients with and without thyroid gland invasion were also analysed. RESULTS: Out of the 133 patients with carcinoma larynx and hypopharynx who underwent surgery, histological thyroid gland invasion was observed in 28/133 (21%) patients. Significant relationship was found between histological thyroid gland invasion and preoperative evidence of thyroid cartilage erosion by CT scan and also when gross thyroid gland involvement observed during surgery. There is significant association between thyroid gland invasion when there is upper oesophageal or subglottic involvement. CONCLUSION: After analysing the retrospective data from our study, we would like to suggest that thyroid gland need not be removed routinely in all laryngectomies, unless there is advanced disease with thyroid cartilage erosion and gross thyroid gland involvement or disease with significant subglottic or oesophageal involvement.
INTRODUCTION: Intraoperative management of thyroid gland in laryngeal and hypopharyngeal cancer is controversial. AIM: The objectives of this study were to determine the incidence of thyroid gland invasion in patients undergoing surgery for laryngeal or hypopharyngeal carcinoma, to assess predictive factors and to assess the prognosis in patients with and without thyroid gland invasion. MATERIALS AND METHODS: One hundred and thirty-three patients who underwent surgery for carcinoma larynx and hypopharynx from 2006 to 2010 were reviewed retrospectively. Surgical specimens were examined to determine the incidence of thyroid gland invasion and predictive factors were analysed. The recurrence rate and the survival in patients with and without thyroid gland invasion were also analysed. RESULTS: Out of the 133 patients with carcinoma larynx and hypopharynx who underwent surgery, histological thyroid gland invasion was observed in 28/133 (21%) patients. Significant relationship was found between histological thyroid gland invasion and preoperative evidence of thyroid cartilage erosion by CT scan and also when gross thyroid gland involvement observed during surgery. There is significant association between thyroid gland invasion when there is upper oesophageal or subglottic involvement. CONCLUSION: After analysing the retrospective data from our study, we would like to suggest that thyroid gland need not be removed routinely in all laryngectomies, unless there is advanced disease with thyroid cartilage erosion and gross thyroid gland involvement or disease with significant subglottic or oesophageal involvement.
Authors: José Francisco Gallegos-Hernández; Gabriel Minauro-Muñoz; Dulce María Hernández-Hernández; Alejandro Flores-Carranza; Martín Hernández-Sanjuán; Jaime Alfonso Reséndiz-Colosia Journal: Cir Cir Date: 2005 Jan-Feb Impact factor: 0.361
Authors: Jae Won Kim; Gil Soo Han; Sung Soo Byun; Dong Youl Lee; Byung Han Cho; Young-Mo Kim Journal: Auris Nasus Larynx Date: 2007-09-11 Impact factor: 1.863