Udayakumar Praveenkumar1, Satyaki Ganguly2, Lopamudra Ray3, Sunil Kumar Nanda4, Sheela Kuruvila5. 1. Student, Pondicherry Institute of Medical Sciences , Pondicherry, India . 2. Associate Professor, Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences , Pondicherry, India . 3. Associate Professor, Department of Biochemistry, Pondicherry Institute of Medical Sciences , Pondicherry, India . 4. Professor, Department of Biochemistry, Pondicherry Institute of Medical Sciences , Pondicherry, India . 5. Professor, Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences , Pondicherry, India .
Abstract
INTRODUCTION: Previous studies indicate a higher prevalence of metabolic syndrome in psoriatic patients. This study aimed to investigate the association of metabolic syndrome and its components with psoriasis. It also studied the relation between presence of metabolic syndrome and disease duration in psoriasis patients. MATERIALS AND METHODS: This was a hospital-based, case-control study conducted with 30 clinically diagnosed patients of chronic plaque psoriasis and 30 age- and sex-matched control subjects. Height, weight, BMI, blood pressure and waist circumference were assessed in all the subjects. Fasting levels of serum glucose, serum triglycerides and serum HDL were estimated by automated clinical chemistry analyser. Metabolic syndrome was diagnosed by the presence of at least 3 criteria of NCEP ATP III with Asian modification for waist circumference. RESULTS: Metabolic syndrome was more common in psoriatic patients than in controls but the difference was statistically insignificant (60% vs. 40%, p-value=0.12). The psoriasis group had a higher prevalence of elevated blood glucose levels and higher waist circumference compared to controls. Psoriasis patients had a higher prevalence of high triglyceride levels than controls, the difference being statistically insignificant (40% vs. 30%, p-value = 0.41). The prevalence of low HDL levels was significantly higher in cases compared to controls (86.7% vs. 60%, p-value = 0.02). There was no relation between presence of metabolic syndrome and duration of psoriasis. CONCLUSION: Our findings suggest that metabolic syndrome as well as dyslipidaemia is commoner in psoriasis patients. This underlines the need for screening of all psoriasis patients for early diagnosis and treatment of associated metabolic syndrome to reduce the high burden of morbidity and mortality.
INTRODUCTION: Previous studies indicate a higher prevalence of metabolic syndrome in psoriaticpatients. This study aimed to investigate the association of metabolic syndrome and its components with psoriasis. It also studied the relation between presence of metabolic syndrome and disease duration in psoriasispatients. MATERIALS AND METHODS: This was a hospital-based, case-control study conducted with 30 clinically diagnosed patients of chronic plaque psoriasis and 30 age- and sex-matched control subjects. Height, weight, BMI, blood pressure and waist circumference were assessed in all the subjects. Fasting levels of serum glucose, serum triglycerides and serum HDL were estimated by automated clinical chemistry analyser. Metabolic syndrome was diagnosed by the presence of at least 3 criteria of NCEP ATP III with Asian modification for waist circumference. RESULTS:Metabolic syndrome was more common in psoriaticpatients than in controls but the difference was statistically insignificant (60% vs. 40%, p-value=0.12). The psoriasis group had a higher prevalence of elevated blood glucose levels and higher waist circumference compared to controls. Psoriasispatients had a higher prevalence of high triglyceride levels than controls, the difference being statistically insignificant (40% vs. 30%, p-value = 0.41). The prevalence of low HDL levels was significantly higher in cases compared to controls (86.7% vs. 60%, p-value = 0.02). There was no relation between presence of metabolic syndrome and duration of psoriasis. CONCLUSION: Our findings suggest that metabolic syndrome as well as dyslipidaemia is commoner in psoriasispatients. This underlines the need for screening of all psoriasispatients for early diagnosis and treatment of associated metabolic syndrome to reduce the high burden of morbidity and mortality.
Authors: Dorothea M Sommer; Stefan Jenisch; Michael Suchan; Enno Christophers; Michael Weichenthal Journal: Arch Dermatol Res Date: 2006-09-22 Impact factor: 3.017
Authors: Simona Vachatova; Ctirad Andrys; Jan Krejsek; Miloslav Salavec; Karel Ettler; Vit Rehacek; Eva Cermakova; Andrea Malkova; Zdenek Fiala; Lenka Borska Journal: J Immunol Res Date: 2016-12-21 Impact factor: 4.818