Literature DB >> 27042527

Mixed Germ Cell Tumour in an Infertile Male Having Unilateral Cryptorchidism: A Rare Case Report.

Anand Singla1, Navneet Kaur2, Gunjeet Sandhu3, Rupesh Nagori1.   

Abstract

Mixed germ cell tumours with multiple components occur more frequently than the pure varieties of germ cell tumours. Embryonal carcinoma and teratoma together form the most common components of the mixed germ cell tumour but the yolk sac tumour is usually seen as a minor component in patients presenting with mixed germ cell tumour. We report a rare case of 27-year-old Hepatitis C positive male presenting with pain in left lower abdomen with associated history of same sided undescended testis and infertility. Right sided testis lying in scrotal sac appeared normal on ultrasonography but patient was azoospermic. He had raised levels of serum markers, alpha feto protein and beta HCG. Examination showed a large mass in left lower abdomen involving the sigmoid colon with the absence of left testis in left scrotum which was confirmed on CT scan. Excision of the mass was done and histopathology examination revealed it as a malignant mixed germ cell tumour composed predominantly of a yolk sac tumour, with minor component as seminoma and embryonal carcinoma in an undescended testis. Following this, the level of serum markers came down. The patient is now undergoing adjuvant chemotherapy and is doing well.

Entities:  

Keywords:  Azoospermia; Cryptorchid testis; Infertility; Malignant mixed germ cell tumour; Yolk sac tumour

Year:  2016        PMID: 27042527      PMCID: PMC4800593          DOI: 10.7860/JCDR/2016/15298.7238

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  10 in total

1.  The single testis: paternity after presentation as unilateral cryptorchidism.

Authors:  Peter A Lee; Michael T Coughlin
Journal:  J Urol       Date:  2002-10       Impact factor: 7.450

Review 2.  Clinical epidemiology of testicular germ cell tumors.

Authors:  K-P Dieckmann; U Pichlmeier
Journal:  World J Urol       Date:  2004-03-18       Impact factor: 4.226

3.  Yolk sac tumour of the cryptorchid testis, with an unusual presentation - diagnosed by fine needle aspiration cytology.

Authors:  Dilip Chandra Barman; Aniket Halder; Sumanta Bhattacharya; Krishnendu Mandal; Sanjay Kumar Mallick
Journal:  J Clin Diagn Res       Date:  2013-07-01

4.  Mixed germ cell tumor complicating an intra-abdominal cryptorchidism.

Authors:  Ahmed Abu-Zaid; Ayman Azzam; Tarek Amin
Journal:  Hematol Oncol Stem Cell Ther       Date:  2013-10-28

5.  Fertility after unilateral cryptorchidism. Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters.

Authors:  K D Miller; M T Coughlin; P A Lee
Journal:  Horm Res       Date:  2001

6.  Pathology of germ cell tumors of testes.

Authors:  F K Mostofi; I A Sesterhenn
Journal:  Prog Clin Biol Res       Date:  1985

7.  Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data.

Authors:  P A Lee; M T Coughlin
Journal:  Horm Res       Date:  2001

8.  Testicular cancer risk in boys with maldescended testis: a cohort study.

Authors:  A Giwercman; J Grindsted; B Hansen; O M Jensen; N E Skakkebaek
Journal:  J Urol       Date:  1987-11       Impact factor: 7.450

Review 9.  Undescended testicle: An update on fertility in cryptorchid men.

Authors:  Prabudh Goel; J D Rawat; A Wakhlu; S N Kureel
Journal:  Indian J Med Res       Date:  2015-02       Impact factor: 2.375

10.  Yolk sac tumor of cryptorchid testis diagnosed by fine needle aspiration cytology.

Authors:  Monisha Choudhury; Shivali Sehgal; Anita Nangia; Rajiv Chadha
Journal:  J Cytol       Date:  2015 Jan-Mar       Impact factor: 1.000

  10 in total
  1 in total

1.  Massive Intra-abdominal Germ Cell Tumors: A Case Series and Review of Literature.

Authors:  Daniel G Wong; Nirmish Singla; Aditya Bagrodia
Journal:  Rev Urol       Date:  2019
  1 in total

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