Ali Momeni1, Morteza Hashemzadeh Chaleshtori2, Saeed Saadatmand3, Soleiman Kheiri4. 1. Associate Professor, Department of Nephrology, Nephrology Division of Internal medicine Department, Shahrekord University of Medical Sciences , Shahrekord, Iran . 2. Professor, Department of Human Genetics, Cellular and Molecular research center, Shahrekord University of Medical Sciences , Shahrekord, Iran . 3. Internist, Department of Internal Medicine Department, Shahrekord University of Medical Sciences , Shahrekord, Iran . 4. Associate Professor, Department of Biostatics, Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences , Iran .
Abstract
BACKGROUND: Nephropathy is the most important leading cause of end stage renal failure in type 2 diabetic patients, so numerous studies were done to diagnose and evaluate risk factors of diabetic nephropathy (DN). Some gene polymorphisms may be associated with progression or regression of DN, so the aim of this study was to compare prevalence of eNOS gene polymorphism in diabetic patients with controls and its association with diabetic nephropathy. MATERIALS AND METHODS: In a cross-sectional study, 94 type 2 diabetic patients and 94 normal participants were enrolled. Patients without retinopathy were excluded from this study. For all of the patients, fasting blood sugar (FBS), 2 hours post-prandial (BS), Blood Urea Nitrogen (BUN), Creatinine (Cr), 24 hours urine protein were measured in the case group. Endothelial nitric oxide synthetase gene polymorphism was evaluated in the case and control groups. RESULTS: There was no significant difference based on age and sex between patients in case and control groups. GG genotype of eNOS was less common in the patient group compared to control group. There was no difference between prevalence of TT, GT or GG genotype based on age and sex. There was no correlation between diabetic retinopathy or proteinuria and genotypes of eNOs. CONCLUSION: The study showed that in type 2 diabetic patients, NOS gene polymorphism was more common compared to normal population; however, there is no correlation between this gene polymorphism and proteinuria or retinopathy in these patients.
BACKGROUND:Nephropathy is the most important leading cause of end stage renal failure in type 2 diabeticpatients, so numerous studies were done to diagnose and evaluate risk factors of diabetic nephropathy (DN). Some gene polymorphisms may be associated with progression or regression of DN, so the aim of this study was to compare prevalence of eNOS gene polymorphism in diabeticpatients with controls and its association with diabetic nephropathy. MATERIALS AND METHODS: In a cross-sectional study, 94 type 2 diabeticpatients and 94 normal participants were enrolled. Patients without retinopathy were excluded from this study. For all of the patients, fasting blood sugar (FBS), 2 hours post-prandial (BS), Blood UreaNitrogen (BUN), Creatinine (Cr), 24 hours urine protein were measured in the case group. Endothelial nitric oxide synthetase gene polymorphism was evaluated in the case and control groups. RESULTS: There was no significant difference based on age and sex between patients in case and control groups. GG genotype of eNOS was less common in the patient group compared to control group. There was no difference between prevalence of TT, GT or GG genotype based on age and sex. There was no correlation between diabetic retinopathy or proteinuria and genotypes of eNOs. CONCLUSION: The study showed that in type 2 diabeticpatients, NOS gene polymorphism was more common compared to normal population; however, there is no correlation between this gene polymorphism and proteinuria or retinopathy in these patients.
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