Z H Huang1, D Z Yang1, Y Q Wei1, Y H Luo1. 1. Zi-He Huang, Yin-Hui Luo, Second Affiliated Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China.
Abstract
AIM: To investigate the effect of fructus aurantii immaturus (FAI) on small intestinal electrical activity in dogs. METHODS: The effect of FAI was observed using a computerized electrophysiological method with the migrating myoelectric complex as a criterion. Fasted, healthy, and conscious dogs were given 100% FAI concentrated solution by gastrostogavage, and as soon as the effect on small intestinal electrical activity appeared, atropine was injected intramuscularly. RESULTS: The enhancing action of FAI was inhibited significantly by atropine, a cholinergic receptor antagonist. Both the number of spike bursts per cluster and the number of spikes per minute in phase II and III and the general cycle were decreased (P < 0.01), although the duration of phase II and the general cycle was prolonged. CONCLUSION: The effect of FAI might be related to the muscarinic receptors.
AIM: To investigate the effect of fructus aurantii immaturus (FAI) on small intestinal electrical activity in dogs. METHODS: The effect of FAI was observed using a computerized electrophysiological method with the migrating myoelectric complex as a criterion. Fasted, healthy, and conscious dogs were given 100% FAI concentrated solution by gastrostogavage, and as soon as the effect on small intestinal electrical activity appeared, atropine was injected intramuscularly. RESULTS: The enhancing action of FAI was inhibited significantly by atropine, a cholinergic receptor antagonist. Both the number of spike bursts per cluster and the number of spikes per minute in phase II and III and the general cycle were decreased (P < 0.01), although the duration of phase II and the general cycle was prolonged. CONCLUSION: The effect of FAI might be related to the muscarinic receptors.
Entities:
Keywords:
Atropine; Electrophysiology; Fructus aurantii immaturus; Small intestine