| Literature DB >> 27041240 |
Jian Wang1, Hai-Feng Wu2, Wei Shen3, Dong-Yan Xu4, Ting-Yan Ruan5, Guo-Qing Tao3, Pei-Hua Lu6.
Abstract
Colon cancer is one of the major causes of cancer-related death in the world. Understanding the molecular mechanism underlying this malignancy will facilitate the diagnosis and treatment. Serine-arginine protein kinase 2 (SRPK2) has been reported to be upregulated in several cancer types. However, its expression and functions in colon cancer remains unknown. In this study, it was found that the expression of SRPK2 was up-regulated in the clinical colon cancer samples. Overexpression of SRPK2 promoted the growth and migration of colon cancer cells, while knocking down the expression of SRPK2 inhibited the growth, migration and tumorigenecity of colon cancer cells. Molecular mechanism studies revealed that SRPK2 activated ERK signaling in colon cancer cells. Taken together, our study demonstrated the tumor promoting roles of SRPK2 in colon cancer cells and SRPK2 might be a promising therapeutic target for colon cancer.Entities:
Keywords: Cell growth and migration; Colon cancer; ERK; SRPK2
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Year: 2016 PMID： 27041240 DOI： 10.1016/j.gene.2016.03.051
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688