Maaike Meurs1, Annelieke M Roest2, Nynke A Groenewold3, Casper F M Franssen4, Ralf Westerhuis5, Wybe Douwe Kloppenburg6, Bennard Doornbos7, Lindy Beukema8, Hanna Lindmäe9, Jan Cees de Groot10, Marie-José van Tol11, Peter de Jonge12. 1. University of Groningen/University Medical Center Groningen, Department of psychiatry - Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), The Netherlands. Electronic address: m.meurs@umcg.nl. 2. University of Groningen/University Medical Center Groningen, Department of psychiatry - Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), The Netherlands. Electronic address: a.m.roest@umcg.nl. 3. University of Groningen/University Medical Center Groningen, Department of psychiatry - Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), The Netherlands. Electronic address: n.a.groenewold01@umcg.nl. 4. University of Groningen/University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, The Netherlands. Electronic address: c.f.m.franssen@umcg.nl. 5. Dialyses Center Groningen, The Netherlands. Electronic address: r.westerhuis@dcg.nl. 6. Martini Ziekenhuis Groningen, Department of Internal Medicine, The Netherlands. Electronic address: kloppenw@mzh.nl. 7. University Medical Center Groningen, department of Psychiatry, the Netherlands, GGZ Drenthe, Assen, the Netherlands. Electronic address: b.doornbos@umcg.nl. 8. University of Groningen/University Medical Center Groningen, Department of psychiatry - Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), The Netherlands. Electronic address: lindy.beukema@gmail.com. 9. University of Groningen/University Medical Center Groningen, department of Radiology, The Netherlands. Electronic address: h.lindmae@umcg.nl. 10. University of Groningen/University Medical Center Groningen, department of Radiology, The Netherlands. Electronic address: j.c.de.groot@umcg.nl. 11. University of Groningen/University Medical Center Groningen, Neuroimaging Center, department of Neuroscience, section Cognitive NeuroPsychiatry, The Netherlands. Electronic address: m.j.van.tol@umcg.nl. 12. University of Groningen/University Medical Center Groningen, Department of psychiatry - Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), The Netherlands. Electronic address: peter.de.jonge@umcg.nl.
Abstract
OBJECTIVE: Chronic kidney disease (CKD) is associated with structural brain damage and with a high prevalence of depression. We therefore investigated structural brain alterations in both gray and white matter in CKD patients, focusing on depression-related (frontal-subcortical) regions. METHOD: This cross-sectional MRI study in 24 CKD patients and 24 age- and sex-matched controls first tested whether CKD was associated with regionally lower gray matter (GM) volumes and more severe white matter lesions (WMLs). In exploratory subanalyses, we examined whether differences were more pronounced in CKD patients with depressive symptoms. RESULTS: CKD patients showed lower global GM volume (P=.04) and more severe WMLs (P=.04) compared to controls. In addition, we found substantial clusters of lower GM in the bilateral orbitofrontal-cortex for CKD patients, which were however nonsignificant after proper multiple-comparison correction. In exploratory analyses for depressed CKD patients, reduced GM clusters were mainly detected within the frontal lobe. WML severity was unrelated to depression. CONCLUSION: CKD was characterized by differences in brain structure. Although subthreshold, lower GM volumes were observed in depression-related brain areas and were more pronounced for depressed patients. There is a need for replication in larger and longitudinal studies to investigate whether WMLs and regional GM reductions may render CKD patients more susceptible for depression.
OBJECTIVE:Chronic kidney disease (CKD) is associated with structural brain damage and with a high prevalence of depression. We therefore investigated structural brain alterations in both gray and white matter in CKDpatients, focusing on depression-related (frontal-subcortical) regions. METHOD: This cross-sectional MRI study in 24 CKDpatients and 24 age- and sex-matched controls first tested whether CKD was associated with regionally lower gray matter (GM) volumes and more severe white matter lesions (WMLs). In exploratory subanalyses, we examined whether differences were more pronounced in CKDpatients with depressive symptoms. RESULTS:CKDpatients showed lower global GM volume (P=.04) and more severe WMLs (P=.04) compared to controls. In addition, we found substantial clusters of lower GM in the bilateral orbitofrontal-cortex for CKDpatients, which were however nonsignificant after proper multiple-comparison correction. In exploratory analyses for depressed CKDpatients, reduced GM clusters were mainly detected within the frontal lobe. WML severity was unrelated to depression. CONCLUSION:CKD was characterized by differences in brain structure. Although subthreshold, lower GM volumes were observed in depression-related brain areas and were more pronounced for depressedpatients. There is a need for replication in larger and longitudinal studies to investigate whether WMLs and regional GM reductions may render CKDpatients more susceptible for depression.
Authors: Michael Kolland; Edith Hofer; Lukas Pirpamer; Daniela Eibl; Christian Enzinger; Alexander R Rosenkranz; Reinhold Schmidt Journal: Aging (Albany NY) Date: 2022-01-13 Impact factor: 5.682
Authors: Sophie Lijdsman; Marsh Königs; Marit S van Sandwijk; Antonia H Bouts; Koen van Hoeck; Huib de Jong; Marc Engelen; Jaap Oosterlaan; Frederike J Bemelman; Kim J Oostrom; Jaap W Groothoff Journal: Pediatr Nephrol Date: 2021-11-20 Impact factor: 3.651