| Literature DB >> 27038927 |
Chinnasamy Dhanalakshmi1, Udaiyappan Janakiraman1, Thamilarasan Manivasagam2, Arokiasamy Justin Thenmozhi1, Musthafa Mohamed Essa3,4,5, Ameer Kalandar6, Mohammed Abdul Sattar Khan7, Gilles J Guillemin8.
Abstract
Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson's disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.Entities:
Keywords: Motor and non-motor symptoms; Oxidative stress, apoptosis; Parkinson’s disease; Vanillin
Mesh：
Substances：
Year: 2016 PMID： 27038927 DOI： 10.1007/s11064-016-1901-5
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996