Literature DB >> 27038400

Screening for toxic phorbol esters in jerky pet treat products using LC-MS.

Upul Nishshanka1, Hiranthi Jayasuriya1, Chaitali Chattopadhaya1, Philip J Kijak1, Pak-Sin Chu1, Renate Reimschuessel2, Andriy Tkachenko2, Olgica Ceric2, Hemakanthi G De Alwis3.   

Abstract

Since 2007, the U.S. FDA's Center for Veterinary Medicine (CVM) has been investigating reports of pets becoming ill after consuming jerky pet treats. Jerky used in pet treats contains glycerin, which can be made from vegetable oil or as a byproduct of biodiesel production. Because some biodiesel is produced using oil from Jatropha curcas, a plant that contains toxic compounds including phorbol esters, CVM developed a liquid chromatography-mass spectrometry (LC-MS) screening method to evaluate investigational jerky samples for the presence of these toxins. Results indicated that the samples analyzed with the new method did not contain Jatropha toxins at or above the lowest concentration tested. Published by Elsevier B.V.

Entities:  

Keywords:  Accurate mass; High resolution; Jatropha curcas; Jerky pet treats; LC–MS method; Phorbol esters

Mesh:

Substances:

Year:  2016        PMID: 27038400      PMCID: PMC4869702          DOI: 10.1016/j.jchromb.2016.03.023

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN: 1570-0232            Impact factor:   3.205


  4 in total

1.  Isolation, stability and bioactivity of Jatropha curcas phorbol esters.

Authors:  Joy S Roach; Rakshit K Devappa; Harinder P S Makkar; Klaus Becker
Journal:  Fitoterapia       Date:  2012-01-09       Impact factor: 2.882

Review 2.  Jatropha toxicity--a review.

Authors:  Rakshit K Devappa; Harinder P S Makkar; Klaus Becker
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2010-08       Impact factor: 6.393

3.  A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12-deoxy-16-hydroxyphorbol.

Authors:  M Hirota; M Suttajit; H Suguri; Y Endo; K Shudo; V Wongchai; E Hecker; H Fujiki
Journal:  Cancer Res       Date:  1988-10-15       Impact factor: 12.701

4.  Novel 12-deoxy-16-hydroxyphorbol diesters isolated from the seed oil of Jatropha curcas.

Authors:  Wilhelm Haas; Heinz Sterk; Martin Mittelbach
Journal:  J Nat Prod       Date:  2002-10       Impact factor: 4.050

  4 in total

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