Wei-Chu Chie1, Jane M Blazeby2,3, Chin-Fu Hsiao4, Herng-Chia Chiu5, Ronnie T Poon6, Naoko Mikoshiba7, Gillian Al-Kadhim8, Nigel Heaton8, Jozer Calara8, Peter Collins9, Katharine Caddick9, Anna Costantini10, Valerie Vilgrain11,12. 1. Department of Public Health, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taiwan. 2. Centre for Surgical Research, School of Social & Community Medicine, University of Bristol, Bristol, UK. 3. Division of Surgery, Head & Neck, University Hospitals Bristol NHS Foundation Trust, Bristol, UK. 4. Division of Clinical Trial Statistics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan. 5. Department of Healthcare Administration and Medical Informatics, Kaoshiung Medical University, Taiwan. 6. Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, Japan. 7. Department of Adult Nursing/Palliative Care Nursing, Graduate School of Medicine, University of Tokyo, Japan. 8. Institute of Liver Studies, King's College Hospital, London, UK. 9. Department of Hepatology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK. 10. Psychoncology Unit, Sant'Andrea Hospital - Faculty of Medicine and Psychology Sapienza, University of Rome, Italy. 11. Assistance-Publique Hôpitaux de Paris, APHP, Hôpital Beaujon, Department of Radiology, Clichy, France. 12. Université Paris Diderot, Sorbonne Paris Cité, INSERM Centre de recherche Biomédicale Bichat Beaujon, Paris, France.
Abstract
AIM: The aim of this study is to explore the possible effects of clinical and cultural characteristics of hepatocellular carcinoma on patients' health-related quality of life (HRQoL). METHODS: Patients with hepatocellular carcinoma from Asian and European countries completed the EORTC QLQ-C30 and the EORTC QLQ-HCC18. Comparisons were made using Student's t-test and Wilcoxon rank-sum test with method of false discovery to correct multiple comparisons. Multiway analysis of variance and model selection were used to assess the effects of clinical characteristics and geographic areas. RESULTS: Two hundred and twenty-seven patients with hepatocellular carcinoma completed questionnaires. After adjusting for demographic and clinical characteristics, Asian patients still had significantly better HRQoL scores in emotional functioning, insomnia, (QLQ-C30) and in sexual interest (QLQ-HCC18). We also found an interaction in physical functioning (QLQ-C30) and fatigue (QLQ-HCC18) between geographic region and marital status, married European had worse HRQoL scores than Asian singles. CONCLUSIONS: Both clinical characteristics and geographic areas affected the HRQoL in with hepatocellular carcinoma. Cultural differences and clinical differences in the pattern of disease due to active surveillance of Asian countries may explain the results.
AIM: The aim of this study is to explore the possible effects of clinical and cultural characteristics of hepatocellular carcinoma on patients' health-related quality of life (HRQoL). METHODS:Patients with hepatocellular carcinoma from Asian and European countries completed the EORTC QLQ-C30 and the EORTC QLQ-HCC18. Comparisons were made using Student's t-test and Wilcoxon rank-sum test with method of false discovery to correct multiple comparisons. Multiway analysis of variance and model selection were used to assess the effects of clinical characteristics and geographic areas. RESULTS: Two hundred and twenty-seven patients with hepatocellular carcinoma completed questionnaires. After adjusting for demographic and clinical characteristics, Asian patients still had significantly better HRQoL scores in emotional functioning, insomnia, (QLQ-C30) and in sexual interest (QLQ-HCC18). We also found an interaction in physical functioning (QLQ-C30) and fatigue (QLQ-HCC18) between geographic region and marital status, married European had worse HRQoL scores than Asian singles. CONCLUSIONS: Both clinical characteristics and geographic areas affected the HRQoL in with hepatocellular carcinoma. Cultural differences and clinical differences in the pattern of disease due to active surveillance of Asian countries may explain the results.
Authors: Kerstin Wohlleber; Patrick Heger; Pascal Probst; Christoph Engel; Markus K Diener; André L Mihaljevic Journal: Qual Life Res Date: 2021-07-20 Impact factor: 4.147