Sang Soo Kim1, Sang Heon Song1, In Joo Kim2, Eun Young Lee3, Su Mi Lee4, Choon Hee Chung5, Ihm Soo Kwak6, Eun Kyung Lee7, Yong Ki Kim8. 1. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. 2. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. Electronic address: injkim@pusan.ac.kr. 3. Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. Electronic address: eylee@sch.ac.kr. 4. Department of Internal Medicine, Dong-A University Hospital, Busan, Korea. 5. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. 6. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. 7. Endocare Pharmacy, Busan, Korea. 8. Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
Abstract
AIM: The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. METHODS: The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥60mL/min/1.73m(2). In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34months (8-50 months). RESULTS: Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r=-0.304, P=0.001; r=0.042, P=0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r=-0.219, P=0.008). In the normoalbuminuria group (n=63), the plasma α-klotho remained significantly associated with a decline in eGFR (r=0.324, P=0.004) in the final model. CONCLUSIONS: It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
AIM: The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. METHODS: The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥60mL/min/1.73m(2). In this prospective observational study, a total of 109 type 2 diabeticpatients were followed up for 34months (8-50 months). RESULTS: Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r=-0.304, P=0.001; r=0.042, P=0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r=-0.219, P=0.008). In the normoalbuminuria group (n=63), the plasma α-klotho remained significantly associated with a decline in eGFR (r=0.324, P=0.004) in the final model. CONCLUSIONS: It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabeticpatients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
Authors: Xiu Hong Yang; Bao Long Zhang; Xiao Meng Zhang; Jin Dong Tong; Yan Hong Gu; Li Li Guo; Hui Min Jin Journal: Oxid Med Cell Longev Date: 2020-08-27 Impact factor: 6.543
Authors: Jung Hwan Bae; Seung Ii Jo; Seong Jin Kim; Jong Min Lee; Ji Hun Jeong; Jeong Suk Kang; Nam-Jun Cho; Sang Soo Kim; Eun Young Lee; Jong-Seok Moon Journal: Cells Date: 2019-04-08 Impact factor: 6.600
Authors: Giuseppe Maltese; Nikolaos Fountoulakis; Richard C Siow; Luigi Gnudi; Janaka Karalliedde Journal: Diabetologia Date: 2017-02-13 Impact factor: 10.122