Gyongyi Horvath1, Zita Petrovszki2, Gabriella Kekesi3, Gabor Tuboly4, Balazs Bodosi5, Janos Horvath6, Peter Gombkötő7, Gyorgy Benedek8, Attila Nagy9. 1. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: horvath.gyongyi@med.u-szeged.hu. 2. Institute of Physical Education and Sport Medicine, Juhász Gyula Faculty of Education, University of Szeged, Hattyas sor 10., H-6725 Szeged, Hungary. Electronic address: petrovszki.zita@med.u-szeged.hu. 3. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: kekesi.gabriella@med.u-szeged.hu. 4. Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6., H-6720 Szeged, Hungary. Electronic address: tuboly.gabor@med.u-szeged.hu. 5. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: bodosi.balazs@med.u-szeged.hu. 6. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: horvath.janos@med.u-szeged.hu. 7. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: gombpeti@gmail.com. 8. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: benedek.gyorgy@med.u-szeged.hu. 9. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary. Electronic address: nagy.attila.1@med.u-szeged.hu.
Abstract
BACKGROUND: Psychiatric disorders are frequently accompanied by changes in brain electrical oscillations and abnormal auditory event related potentials. The goal of this study was to characterize these parameters of a new rat substrain showing several alterations related to schizophrenia. METHODS: Male rats of the new substrain, developed by selective breeding after combined subchronic ketamine treatment and postweaning social isolation, and naive Wistar ones group-housed without any interventions were involved in the present study. At the age of 3 months, animals were implanted with cortical electroencephalography electrodes. Auditory evoked potentials during paired-click stimuli and power of oscillation in different frequency bands were determined with and without acute ketamine (20mg/kg) treatment. RESULTS: Regarding the auditory evoked potentials, the latency of P2 was delayed and the amplitude of N1 peak was lower in the new substrain. The new substrain showed increased power of oscillations in the theta, alpha and beta bands, while decreased power was detected in delta and gamma2 bands (52-70Hz) compared with control animals. Acute ketamine treatment increased the gamma1 band (30-48Hz) power in both groups, while it elicited significant changes only in the new substrain in the total power and in alpha, beta and gamma2 bands. CONCLUSIONS: The validation of the translational utility of this new rat substrain by electrophysiological investigations revealed that these rats show abnormalities that may model a part of the neurophysiological deficits observed in schizophrenia.
BACKGROUND:Psychiatric disorders are frequently accompanied by changes in brain electrical oscillations and abnormal auditory event related potentials. The goal of this study was to characterize these parameters of a new rat substrain showing several alterations related to schizophrenia. METHODS: Male rats of the new substrain, developed by selective breeding after combined subchronic ketamine treatment and postweaning social isolation, and naive Wistar ones group-housed without any interventions were involved in the present study. At the age of 3 months, animals were implanted with cortical electroencephalography electrodes. Auditory evoked potentials during paired-click stimuli and power of oscillation in different frequency bands were determined with and without acute ketamine (20mg/kg) treatment. RESULTS: Regarding the auditory evoked potentials, the latency of P2 was delayed and the amplitude of N1 peak was lower in the new substrain. The new substrain showed increased power of oscillations in the theta, alpha and beta bands, while decreased power was detected in delta and gamma2 bands (52-70Hz) compared with control animals. Acute ketamine treatment increased the gamma1 band (30-48Hz) power in both groups, while it elicited significant changes only in the new substrain in the total power and in alpha, beta and gamma2 bands. CONCLUSIONS: The validation of the translational utility of this new rat substrain by electrophysiological investigations revealed that these rats show abnormalities that may model a part of the neurophysiological deficits observed in schizophrenia.
Authors: Leatitia Gabriella Adlan; Mátyás Csordás-Nagy; Balázs Bodosi; György Kalmár; László G Nyúl; Attila Nagy; Gabriella Kekesi; Alexandra Büki; Gyongyi Horvath Journal: Front Behav Neurosci Date: 2022-01-28 Impact factor: 3.558