Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control.

Mitochondria are essential organelles for many fundamental cellular processes, including energy production, fatty acid β-oxidation, metabolite synthesis, iron and calcium homeostasis, and programmed cell death. Mitochondrial quality thus influences not only individual cell functions but also whole body metabolism. Dysregulated mitochondrial quality control is closely associated with the progression of aging related diseases, such as cancers and neurodegenerative disorders. Mitochondrial quality is monitored at the protein, organelle and sub-organelle levels. The critical issues are how stresses such as bioenergetic stress, oxidative stress and proteotoxic stress, are sensed and how the mitochondrial events are coordinated. Recently, several receptors were identified to mediate selective mitophagy, which is essential for mitochondrial quality control in yeast and mammalian cells. It is emerging that these receptors sense distinct stress signals and couple mitophagy machineries with mitochondrial fission/fusion machineries for mitochondrial quality control. Herein, we will review recent advances in receptors mediated mitophagy and mitochondrial dynamics for mitochondrial quality control, with attempt to have an integrative view on the molecular mechanisms for mitochondrial quality control.