David Unuane1, Brigitte Velkeniers2, Sander Deridder3, Bert Bravenboer2, Herman Tournaye4, Michael De Brucker5. 1. Department of Endocrinology, Universitair Ziekenhuis Brussel, Brussels, Belgium. Electronic address: david.unuane@uzbrussel.be. 2. Department of Endocrinology, Universitair Ziekenhuis Brussel, Brussels, Belgium. 3. Department of Engineering and Statistics, Universitair Ziekenhuis Brussel, Brussels, Belgium. 4. Department of Gynecology and Fertility, Universitair Ziekenhuis Brussel, Brussels, Belgium. 5. Department of Gynecology and Fertility, Universitair Ziekenhuis Brussel, Brussels, Belgium; Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Tivoli, La Louvière, Belgium.
Abstract
OBJECTIVE: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI. DESIGN: Retrospective cohort study performed at the Center for Reproductive Medicine and Department of Endocrinology, University Hospital of Brussels, approved by the institutional review board of the hospital. SETTING: University hospital. PATIENT(S): All patients who started their first IVF/intracytoplasmic sperm injection cycle at our fertility center between January 1, 2010 and December 31, 2011 were included. MAIN OUTCOME MEASURE(S): Live birth delivery after 25 weeks' gestation was taken as the primary endpoint of our study Cumulative delivery rates were calculated for both groups until six treatment cycles. INTERVENTION(S): All patients (in both groups) received the usual IVF treatment protocols (i.e., antagonist or agonist protocol). RESULT(S): In total 2,406 women who consulted our center were included. We included 333 patients with TAI and 2019 patients without TAI. In the TAI group the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 65%. In our control the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 76%. CONCLUSION(S): Our study did not confirm an influence of TAI status in patients undergoing fertility treatment on cumulative delivery rates after six IVF/intracytoplasmic sperm injection cycles.
OBJECTIVE: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI. DESIGN: Retrospective cohort study performed at the Center for Reproductive Medicine and Department of Endocrinology, University Hospital of Brussels, approved by the institutional review board of the hospital. SETTING: University hospital. PATIENT(S): All patients who started their first IVF/intracytoplasmic sperm injection cycle at our fertility center between January 1, 2010 and December 31, 2011 were included. MAIN OUTCOME MEASURE(S): Live birth delivery after 25 weeks' gestation was taken as the primary endpoint of our study Cumulative delivery rates were calculated for both groups until six treatment cycles. INTERVENTION(S): All patients (in both groups) received the usual IVF treatment protocols (i.e., antagonist or agonist protocol). RESULT(S): In total 2,406 women who consulted our center were included. We included 333 patients with TAI and 2019patients without TAI. In the TAI group the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 65%. In our control the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 76%. CONCLUSION(S): Our study did not confirm an influence of TAI status in patients undergoing fertility treatment on cumulative delivery rates after six IVF/intracytoplasmic sperm injection cycles.
Authors: S La Vignera; G Defeudis; R Mazzilli; S Medenica; A M Di Tommaso; G Fabozzi; V Zamponi; D Cimadomo; L Rienzi; F M Ubaldi; M Watanabe; A Faggiano Journal: J Endocrinol Invest Date: 2022-08-09 Impact factor: 5.467
Authors: Aimee Seungdamrong; Anne Z Steiner; Clarisa R Gracia; Richard S Legro; Michael P Diamond; Christos Coutifaris; William D Schlaff; Peter Casson; Gregory M Christman; Randal D Robinson; Hao Huang; Ruben Alvero; Karl R Hansen; Susan Jin; Esther Eisenberg; Heping Zhang; Nanette Santoro Journal: Fertil Steril Date: 2017-10-25 Impact factor: 7.329