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Literature DB >> 27036144

Keeping it simple: lessons from the golden era of antibiotic discovery.

Dane Lyddiard¹, Graham L Jones², Ben W Greatrex².

Abstract

Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time, little progress has been made in discovering new antibacterial drugs to combat resistant organisms. History teaches us that 'high tech' target-based complex methods are not synonymous with success and a return to simple, systematic screening of natural products against bacteria from traditional and novel resources holds our greatest hope of success. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords: antibacterial; antibiotic; drug discovery; history; natural products; screening

Mesh：

Substances：

Year: 2016 PMID： 27036144 DOI： 10.1093/femsle/fnw084

Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742

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Cited

8 in total

Review 1. Antibiotic resistance: bioinformatics-based understanding as a functional strategy for drug design.

Authors: Umar Ndagi; Abubakar A Falaki; Maryam Abdullahi; Monsurat M Lawal; Mahmoud E Soliman
Journal: RSC Adv Date: 2020-05-14 Impact factor: 4.036

Review 2. Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies.

Authors: Vera Alexandra Spirescu; Cristina Chircov; Alexandru Mihai Grumezescu; Bogdan Ștefan Vasile; Ecaterina Andronescu
Journal: Int J Mol Sci Date: 2021-04-27 Impact factor: 5.923

3. Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains.

Authors: Silvia Di Lodovico; Edoardo Napoli; Emanuela Di Campli; Paola Di Fermo; Davide Gentile; Giuseppe Ruberto; Antonia Nostro; Emanuela Marini; Luigina Cellini; Mara Di Giulio
Journal: Sci Rep Date: 2019-03-15 Impact factor: 4.379

Review 4. From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products.

Authors: Nicholas John Sadgrove; Graham Lloyd Jones
Journal: Front Microbiol Date: 2019-10-31 Impact factor: 5.640

5. Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis.

Authors: Márió Gajdács; Zoltán Bátori; Marianna Ábrók; Andrea Lázár; Katalin Burián
Journal: Life (Basel) Date: 2020-02-11

Keeping it simple: lessons from the golden era of antibiotic discovery.

Review 1. Antibiotic resistance: bioinformatics-based understanding as a functional strategy for drug design.

Review 2. Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies.

3. Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains.

Review 4. From Petri Dish to Patient: Bioavailability Estimation and Mechanism of Action for Antimicrobial and Immunomodulatory Natural Products.

5. Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis.

6. Membrane-Active Antibacterial Agents Based on Calix[4]arene Derivatives: Synthesis and Biological Evaluation.

Review 7. Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing.

8. Developing Actinobacterial Endophytes as Biocontrol Products for Fusarium pseudograminearum in Wheat.