Literature DB >> 27035812

The biology and function of exosomes in cancer.

Raghu Kalluri.   

Abstract

Humans circulate quadrillions of exosomes at all times. Exosomes are a class of extracellular vesicles released by all cells, with a size range of 40-150 nm and a lipid bilayer membrane. Exosomes contain DNA, RNA, and proteins. Exosomes likely remove excess and/or unnecessary constituents from the cells, functioning like garbage bags, although their precise physiological role remains unknown. Additionally, exosomes may mediate specific cell-to-cell communication and activate signaling pathways in cells they fuse or interact with. Exosomes are detected in the tumor microenvironment, and emerging evidence suggests that they play a role in facilitating tumorigenesis by regulating angiogenesis, immunity, and metastasis. Circulating exosomes can be used as liquid biopsies and noninvasive biomarkers for early detection, diagnosis, and treatment of cancer patients.

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Year:  2016        PMID： 27035812      PMCID： PMC4811149          DOI： 10.1172/JCI81135

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  99 in total

1.  Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes.

Authors:  L Zitvogel; A Regnault; A Lozier; J Wolfers; C Flament; D Tenza; P Ricciardi-Castagnoli; G Raposo; S Amigorena
Journal:  Nat Med       Date:  1998-05       Impact factor: 53.440

2.  Protein targeting to exosomes/microvesicles by plasma membrane anchors.

Authors:  Beiyi Shen; Ning Wu; Jr-Ming Yang; Stephen J Gould
Journal:  J Biol Chem       Date:  2011-02-07       Impact factor: 5.157

3.  Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

Authors:  Mirjam C Boelens; Tony J Wu; Barzin Y Nabet; Bihui Xu; Yu Qiu; Taewon Yoon; Diana J Azzam; Christina Twyman-Saint Victor; Brianne Z Wiemann; Hemant Ishwaran; Petra J Ter Brugge; Jos Jonkers; Joyce Slingerland; Andy J Minn
Journal:  Cell       Date:  2014-10-23       Impact factor: 41.582

4.  Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.

Authors:  Jung Eun Park; Hon Sen Tan; Arnab Datta; Ruenn Chai Lai; Huoming Zhang; Wei Meng; Sai Kiang Lim; Siu Kwan Sze
Journal:  Mol Cell Proteomics       Date:  2010-02-01       Impact factor: 5.911

5.  Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma.

Authors:  Youhei Tanaka; Hidenobu Kamohara; Kouichi Kinoshita; Junji Kurashige; Takatsugu Ishimoto; Masaaki Iwatsuki; Masayuki Watanabe; Hideo Baba
Journal:  Cancer       Date:  2012-12-07       Impact factor: 6.860

6.  Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules.

Authors:  Inkyu Hwang; Xuefei Shen; Jonathan Sprent
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-12       Impact factor: 11.205

7.  Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

Authors:  Weiying Zhou; Miranda Y Fong; Yongfen Min; George Somlo; Liang Liu; Melanie R Palomares; Yang Yu; Amy Chow; Sean Timothy Francis O'Connor; Andrew R Chin; Yun Yen; Yafan Wang; Eric G Marcusson; Peiguo Chu; Jun Wu; Xiwei Wu; Arthur Xuejun Li; Zhuo Li; Hanlin Gao; Xiubao Ren; Mark P Boldin; Pengnian Charles Lin; Shizhen Emily Wang
Journal:  Cancer Cell       Date:  2014-04-14       Impact factor: 31.743

8.  Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes.

Authors:  F A San Lucas; K Allenson; V Bernard; J Castillo; D U Kim; K Ellis; E A Ehli; G E Davies; J L Petersen; D Li; R Wolff; M Katz; G Varadhachary; I Wistuba; A Maitra; H Alvarez
Journal:  Ann Oncol       Date:  2015-12-17       Impact factor: 32.976

Review 9.  Extracellular vesicles: emerging targets for cancer therapy.

Authors:  Pieter Vader; Xandra O Breakefield; Matthew J A Wood
Journal:  Trends Mol Med       Date:  2014-04-03       Impact factor: 11.951

10.  Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets.

Authors:  Laurent Muller; Masato Mitsuhashi; Patricia Simms; William E Gooding; Theresa L Whiteside
Journal:  Sci Rep       Date:  2016-02-04       Impact factor: 4.379
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  544 in total

1.  Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation.

Authors:  Karoliina Stefanius; Kelly Servage; Marcela de Souza Santos; Hillery Fields Gray; Jason E Toombs; Suneeta Chimalapati; Min S Kim; Venkat S Malladi; Rolf Brekken; Kim Orth
Journal:  Elife       Date:  2019-05-28       Impact factor: 8.140

Review 2.  Liver metastases.

Authors:  Diamantis I Tsilimigras; Pnina Brodt; Pierre-Alain Clavien; Ruth J Muschel; Michael I D'Angelica; Itaru Endo; Rowan W Parks; Majella Doyle; Eduardo de Santibañes; Timothy M Pawlik
Journal:  Nat Rev Dis Primers       Date:  2021-04-15       Impact factor: 52.329

3.  Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation.

Authors:  Jialin Chen; Renpeng Zhou; Yimin Liang; Xiujun Fu; Danru Wang; Chen Wang
Journal:  FASEB J       Date:  2019-08-20       Impact factor: 5.191

4.  3D in vitro model for human corneal endothelial cell maturation.

Authors:  Audrey E K Hutcheon; James D Zieske; Xiaoqing Guo
Journal:  Exp Eye Res       Date:  2019-04-10       Impact factor: 3.467

Review 5.  Exosomal therapy-a new frontier in regenerative medicine.

Authors:  Sathish Muthu; Asawari Bapat; Rashmi Jain; Naveen Jeyaraman; Madhan Jeyaraman
Journal:  Stem Cell Investig       Date:  2021-04-02

6.  Tumor-derived exosomal circRNA051239 promotes proliferation and migration of epithelial ovarian cancer.

Authors:  Ruiqiong Ma; Xue Ye; Hongyan Cheng; Heng Cui; Xiaohong Chang
Journal:  Am J Transl Res       Date:  2021-03-15       Impact factor: 4.060

7.  Not all extracellular vesicles were created equal: clinical implications.

Authors:  Alberto Ortiz
Journal:  Ann Transl Med       Date:  2017-03

8.  An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

Authors:  Angelica Ortiz; Jun Gui; Farima Zahedi; Pengfei Yu; Christina Cho; Sabyasachi Bhattacharya; Christopher J Carbone; Qiujing Yu; Kanstantsin V Katlinski; Yuliya V Katlinskaya; Simran Handa; Victor Haas; Susan W Volk; Angela K Brice; Kim Wals; Nicholas J Matheson; Robin Antrobus; Sonja Ludwig; Theresa L Whiteside; Cindy Sander; Ahmad A Tarhini; John M Kirkwood; Paul J Lehner; Wei Guo; Hallgeir Rui; Andy J Minn; Constantinos Koumenis; J Alan Diehl; Serge Y Fuchs
Journal:  Cancer Cell       Date:  2019-01-14       Impact factor: 31.743

9.  Differential in vivo biodistribution of 131I-labeled exosomes from diverse cellular origins and its implication for theranostic application.

Authors:  Mohammad H Rashid; Thaiz F Borin; Roxan Ara; Kartik Angara; Jingwen Cai; Bhagelu R Achyut; Yutao Liu; Ali S Arbab
Journal:  Nanomedicine       Date:  2019-08-01       Impact factor: 5.307

10.  Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation.

Authors:  Do-Kyun Kim; Young-Eun Cho; Hirsh D Komarow; Geethani Bandara; Byoung-Joon Song; Ana Olivera; Dean D Metcalfe
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-23       Impact factor: 11.205
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