Alper Yazici1, Esin Sogutlu Sari1, Rabia Koc2, Gozde Sahin1, Huseyin Kurt3, Pinar Cakar Ozdal4, Sitki Samet Ermis1. 1. Department of Ophthalmology Balikesir University School of Medicine, Balikesir, Turkey. 2. Department of Neurology, Balikesir University School of Medicine, Balikesir, Turkey. 3. Department of Internal Medicine, Balikesir University School of Medicine, Balikesir, Turkey. 4. Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Abstract
PURPOSE: To evaluate the effect of diabetic polyneuropathy on choroidal thickness in type 2 diabetes patients. METHODS: Forty-one diabetic polyneuropathy (DPN) patients with no or mild retinopathy, 50 non-DPN diabetic patients with no or mild retinopathy, and 42 healthy controls without any retinal complaint were included in the study. All participants underwent detailed ophthalmic examinations. Choroidal thickness (CT) measurements were performed by the same independent technician in the morning between 9 and 11 AM to avoid diurnal variations. Perpendicular CT was measured from the outer edge of the hyperreflective retinal pigment epithelium to the inner sclera at seven locations: the fovea; and 500, 1000, and 1500 μm temporally and nasally to the fovea. RESULTS: The groups were age and sex matched (P > 0.05). The mean subfoveal CT values were significantly different in groups with a thickening trend from control to non-DPN and DPN (P < 0.01). The mean values for subfoveal CT in control, non-DPN, and DPN groups were 241.12 ± 52.71, 279.82 ± 51.42, and 304.71 ± 54.92 μm, respectively. The same thickening trend was also evident in all other six measurement points with statistical significance (P < 0.01). CONCLUSIONS: Diabetic patients had increased CT compared to healthy controls. The presence of neuropathy in diabetes patients caused additional choroidal thickening, compared to nonneuropathic patients.
PURPOSE: To evaluate the effect of diabetic polyneuropathy on choroidal thickness in type 2 diabetespatients. METHODS: Forty-one diabetic polyneuropathy (DPN) patients with no or mild retinopathy, 50 non-DPN diabeticpatients with no or mild retinopathy, and 42 healthy controls without any retinal complaint were included in the study. All participants underwent detailed ophthalmic examinations. Choroidal thickness (CT) measurements were performed by the same independent technician in the morning between 9 and 11 AM to avoid diurnal variations. Perpendicular CT was measured from the outer edge of the hyperreflective retinal pigment epithelium to the inner sclera at seven locations: the fovea; and 500, 1000, and 1500 μm temporally and nasally to the fovea. RESULTS: The groups were age and sex matched (P > 0.05). The mean subfoveal CT values were significantly different in groups with a thickening trend from control to non-DPN and DPN (P < 0.01). The mean values for subfoveal CT in control, non-DPN, and DPN groups were 241.12 ± 52.71, 279.82 ± 51.42, and 304.71 ± 54.92 μm, respectively. The same thickening trend was also evident in all other six measurement points with statistical significance (P < 0.01). CONCLUSIONS:Diabeticpatients had increased CT compared to healthy controls. The presence of neuropathy in diabetespatients caused additional choroidal thickening, compared to nonneuropathicpatients.
Authors: Yong Un Shin; Sang Eun Lee; Min Ho Kang; Sang-Woong Han; Joo-Hark Yi; Heeyoon Cho Journal: Medicine (Baltimore) Date: 2019-05 Impact factor: 1.817