A Böhm1, L Tothova2, L Urban3, P Slezak4, L Bacharova5, P Musil6, R Hatala7. 1. National Institute of Cardiovascular Diseases, Bratislava, Slovakia; Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia. Electronic address: allan.bohm@gmail.com. 2. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; Faculty of Medicine, Comenius University, Bratislava, Slovakia. 3. National Institute of Cardiovascular Diseases, Bratislava, Slovakia. 4. Faculty of Medicine, Comenius University, Bratislava, Slovakia. 5. Faculty of Medicine, Comenius University, Bratislava, Slovakia; International Laser Center, Comenius University, Bratislava, Slovakia. 6. Faculty of Pharmacy, Comenius University, Bratislava, Slovakia. 7. National Institute of Cardiovascular Diseases, Bratislava, Slovakia; Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
Abstract
INTRODUCTION: The current paradigm claims a link between oxidative stress and atrial fibrillation. The aim of our research was to study a relation between the percentage of time spent in atrial fibrillation (AF burden) and concentrations of oxidative stress biomarkers, before and after pulmonary veins isolation (PVI). METHODOLOGY: We included 19 patients (mean age 55±10years, 4 females and 15 males) with implanted loop recorders undergoing PVI. Plasmatic concentrations of advanced glycation end-products (AGEs), fructosamine, advanced oxidation protein products and thiobarbituric-acid reacting substances (TBARS) were measured and AF burden was recorded immediately before and 3months after the PVI. AF burden was also recorded 9months after the PVI. RESULTS: Post procedural AGEs concentration significantly negatively correlated with AF burden after 3months (ρ=-0.63; p<0.01) and 9months (ρ=-0.5; p=0.04), respectively as well as TBARS concentration significantly negatively correlated with AF burden after 9months (ρ=-0.61; p=0.01). CONCLUSION: Our study showed AGEs and TBARS to be potential predictors for AF burden after the PVI. We suppose that the more oxidative stress after the PVI is provoked, the more fibrotic tissue is produced. That means a better electrical isolation of pulmonary veins and consequently a lower AF burden.
INTRODUCTION: The current paradigm claims a link between oxidative stress and atrial fibrillation. The aim of our research was to study a relation between the percentage of time spent in atrial fibrillation (AF burden) and concentrations of oxidative stress biomarkers, before and after pulmonary veins isolation (PVI). METHODOLOGY: We included 19 patients (mean age 55±10years, 4 females and 15 males) with implanted loop recorders undergoing PVI. Plasmatic concentrations of advanced glycation end-products (AGEs), fructosamine, advanced oxidation protein products and thiobarbituric-acid reacting substances (TBARS) were measured and AF burden was recorded immediately before and 3months after the PVI. AF burden was also recorded 9months after the PVI. RESULTS: Post procedural AGEs concentration significantly negatively correlated with AF burden after 3months (ρ=-0.63; p<0.01) and 9months (ρ=-0.5; p=0.04), respectively as well as TBARS concentration significantly negatively correlated with AF burden after 9months (ρ=-0.61; p=0.01). CONCLUSION: Our study showed AGEs and TBARS to be potential predictors for AF burden after the PVI. We suppose that the more oxidative stress after the PVI is provoked, the more fibrotic tissue is produced. That means a better electrical isolation of pulmonary veins and consequently a lower AF burden.
Authors: Allan Bohm; Lubos Urban; Lubomira Tothova; Ljuba Bacharova; Peter Musil; Jan Kyselovic; Peter Michalek; Tomas Uher; Branislav Bezak; Peter Olejnik; Robert Hatala Journal: J Interv Card Electrophysiol Date: 2021-03-10 Impact factor: 1.900
Authors: David Bode; Lukas Semmler; Christian U Oeing; Alessio Alogna; Gabriele G Schiattarella; Burkert M Pieske; Frank R Heinzel; Felix Hohendanner Journal: Int J Mol Sci Date: 2021-05-31 Impact factor: 5.923