Mi Sung Kim1, Byung Ik Kim2, Heon-Ju Kwon3, Hae Won Park3, Hee-Jin Park3, Ki Bae Bang4, Hyun Pyo Hong3, Myung Ho Rho3. 1. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. misung70@gmail.com. 2. Department of Gastroenterology and Hepatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. 3. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. 4. Department of Gastroenterology and Hepatology, Dankook University Hospital, 108 Pyong dong, Jongro-gu, Seoul, 110-746, Korea.
Abstract
PURPOSE: To investigate the frequency of discordance and to identify factors associated with discordance between ultrasonographic and elastographic grades for assessing hepatic fibrosis in Asian patients with chronic hepatitis B. METHODS: Three hundred thirty-four patients with chronic hepatitis B for which both conventional ultrasonography and liver stiffness measurements using elastography were available were included. Patients were graded as 'normal', 'chronic liver disease', or 'liver cirrhosis' by ultrasonography, and as 'no significant fibrosis', 'significant fibrosis', or 'liver cirrhosis' by elastography, and the results of these two modalities were compared. Logistic regression analyses were performed to identify independent factors associated with discordant results. RESULTS: Of the 334 patients, 153 (45.8 %), 115 (34.4 %), and 66 (19.8 %) patients were 'normal', 'chronic liver disease', and 'liver cirrhosis', respectively, based on the ultrasonographic grades, and 290 (86.8 %), 29 (8.7 %), and 15 (4.5 %) patients were 'no significant fibrosis,' 'significant fibrosis', and 'liver cirrhosis', respectively, based on the elastographic values. Among them, 173 (51.8 %) showed discordance with respect to severity of hepatic fibrosis. In multivariable analysis, discordance was more frequent in patients with ultrasonographic grades of 'chronic liver disease' [adjusted odds ratio (AOR), 1924; P < 0.001] and 'liver cirrhosis' (AOR, 4498; P < 0.001), whereas patients with an elastographic grade of 'liver cirrhosis' showed a negative association with discordance (AOR, 0.002; P = 0.007). CONCLUSION: There was a high rate of discordance between hepatic fibrosis grades determined by ultrasonography and elastography. Considering the accuracy of liver stiffness evaluation by elastography, conventional ultrasonography might overestimate hepatic fibrosis in chronic hepatitis B.
PURPOSE: To investigate the frequency of discordance and to identify factors associated with discordance between ultrasonographic and elastographic grades for assessing hepatic fibrosis in Asian patients with chronic hepatitis B. METHODS: Three hundred thirty-four patients with chronic hepatitis B for which both conventional ultrasonography and liver stiffness measurements using elastography were available were included. Patients were graded as 'normal', 'chronic liver disease', or 'liver cirrhosis' by ultrasonography, and as 'no significant fibrosis', 'significant fibrosis', or 'liver cirrhosis' by elastography, and the results of these two modalities were compared. Logistic regression analyses were performed to identify independent factors associated with discordant results. RESULTS: Of the 334 patients, 153 (45.8 %), 115 (34.4 %), and 66 (19.8 %) patients were 'normal', 'chronic liver disease', and 'liver cirrhosis', respectively, based on the ultrasonographic grades, and 290 (86.8 %), 29 (8.7 %), and 15 (4.5 %) patients were 'no significant fibrosis,' 'significant fibrosis', and 'liver cirrhosis', respectively, based on the elastographic values. Among them, 173 (51.8 %) showed discordance with respect to severity of hepatic fibrosis. In multivariable analysis, discordance was more frequent in patients with ultrasonographic grades of 'chronic liver disease' [adjusted odds ratio (AOR), 1924; P < 0.001] and 'liver cirrhosis' (AOR, 4498; P < 0.001), whereas patients with an elastographic grade of 'liver cirrhosis' showed a negative association with discordance (AOR, 0.002; P = 0.007). CONCLUSION: There was a high rate of discordance between hepatic fibrosis grades determined by ultrasonography and elastography. Considering the accuracy of liver stiffness evaluation by elastography, conventional ultrasonography might overestimate hepatic fibrosis in chronic hepatitis B.
Authors: C Aubé; F Oberti; N Korali; M A Namour; D Loisel; J Y Tanguy; E Valsesia; C Pilette; M C Rousselet; P Bedossa; H Rifflet; M Y Maïga; D Penneau-Fontbonne; C Caron; P Calès Journal: J Hepatol Date: 1999-03 Impact factor: 25.083
Authors: In Ku Yo; Oh Sang Kwon; Jin Woong Park; Jong Joon Lee; Jung Hyun Lee; In Sik Won; Sun Young Na; Pil Kyu Jang; Pyung Hwa Park; Duck Joo Choi; Yun Soo Kim; Ju Hyun Kim Journal: Clin Mol Hepatol Date: 2015-03-25