Ronggui Hu1,2,3, Mark Hochstrasser4,5. 1. Key Laboratory of Systems Biology, University of Chinese Academy of Sciences; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China. 2. CAS Center for Excellence in Molecular and Cell Science, University of Chinese Academy of Sciences; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China. 3. Innovation Center for Cell Signaling Network, University of Chinese Academy of Sciences; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China. 4. Department of Molecular Biophysics & Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA. 5. Department of Molecular, Cellular, & Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.