Literature DB >> 27032333

A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells.

Thanya Rukkijakan1, Lukana Ngiwsara2, Kriengsak Lirdprapamongkol3, Jisnuson Svasti3, Nared Phetrak1, Pitak Chuawong4.   

Abstract

A series of 2,3-diarylindoles were synthesized via the Larock heteroannulation, and evaluated for their anticancer activity against A549 lung cancer cells. The most potent compound, PCNT13 with IC50=5.17 μM, caused the induction of two modes of programmed cell death, apoptosis and autophagy.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  2,3-Diarylindole; Apoptosis; Autophagy; Lung cancer

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Year:  2016        PMID： 27032333     DOI： 10.1016/j.bmcl.2016.03.079

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

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Authors:  Sheng Tang; Zhihui Zhou; Zhiyan Jiang; Wufu Zhu; Dan Qiao
Journal:  Molecules       Date:  2022-02-28       Impact factor: 4.411

3.  JAK2/STAT3‑mediated dose‑dependent cytostatic and cytotoxic effects of sesquiterpene lactones from Gymnanthemum extensum on A549 human lung carcinoma cells.

Authors:  Siriporn Keeratichamroen; Kriengsak Lirdprapamongkol; Sanit Thongnest; Jutatip Boonsombat; Pornsuda Chawengrum; Thiwaree Sornprachum; Jitnapa Sirirak; Chris Verathamjamras; Narittira Ornnork; Somsak Ruchirawat; Jisnuson Svasti
Journal:  Oncol Rep       Date:  2021-11-05       Impact factor: 3.906
  3 in total

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