| Literature DB >> 27031245 |
Shigeo Hanada, Satoshi Iwata, Kazuma Kishi, Miyuki Morozumi, Naoko Chiba, Takeaki Wajima, Misako Takata, Kimiko Ubukata.
Abstract
Entities:
Year: 2016 PMID: 27031245 PMCID: PMC4816381 DOI: 10.1371/journal.pone.0153109
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Risk factors associated with mortality within 28 days among patients with invasive pneumococcal disease by multivariate logistic regression analysis.
| Characteristic | Survived (n = 384) | Died (n = 122) | Multivariate analysis | |
|---|---|---|---|---|
| n (%) | n (%) | OR (95% CI) | ||
| <50 y | 45 (11.7) | 5 (4.1) | 1 | - |
| 50–64 y | 87 (22.7) | 18 (14.8) | 1.6 (0.5–5.6) | NS |
| 65–79 y | 155 (40.4) | 51 (41.8) | 3.0 (0.9–9.6) | NS |
| ≥80 y | 97 (25.3) | 48 (39.3) | 6.5 (2.0–21.6) | .002 |
| Liver disease | 33 (8.6) | 17 (13.9) | 3.5 (1.6–7.8) | .002 |
| Lung disease | 34 (8.9) | 4 (3.3) | 0.4 (0.1–1.4) | NS |
| 52 (13.5) | 40 (32.8) | 3.0 (1.7–5.6) | < .001 | |
| WBC (<4.0×103 cells/μL) | 39 (10.2) | 41 (33.6) | 6.9 (3.7–12.8) | < .001 |
| Cr (≥2.0 mg/dL) | 46 (12.1) | 44 (36.4) | 4.5 (2.5–8.1) | < .001 |
| LDH (≥300 IU/L) | 118 (32.1) | 61 (53.0) | 2.4 (1.4–4.0) | .001 |
| PCV7 serotypes | 139 (36.2) | 44 (36.1) | 1 | - |
| PCV13 and PPSV23 serotypes | 182 (47.4) | 50 (41.0) | 0.8 (0.5–1.5) | NS |
| Non-vaccine serotypes | 60 (15.6) | 20 (23.0) | 1.5 (0.8–3.0) | NS |
a Includes chronic hepatitis or cirrhosis that was secondary to alcohol abuse or viral infection.
b Includes chronic obstructive pulmonary disease, bronchial asthma, interstitial lung disease, and bronchiectasis.
c Laboratory findings; WBC, white blood cell count; Cr, creatinine; LDH, lactate dehydrogenase.
d Serotype; PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine.
e Multivariate analysis; OR, odds ratio; CI, confidence interval.
f NS, not significant (p ≥ .05).