Jiantao Wang1, Jian Lv2, Wanchun Wang3, Xiubo Jiang1. 1. Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, Qingdao, Shandong Province, China. 2. Department of Prevention, Qingdao Stomatological Hospital, Qingdao, Shandong Province, China. 3. Department of Periodontology and Oral Mucosal Diseases, Qingdao Stomatological Hospital, Qingdao, Shandong Province, China.
Abstract
AIM: A meta-analysis was conducted to quantitatively summarize the evidence from observational studies on alcohol consumption and risk of periodontitis. MATERIAL AND METHODS: A comprehensive literature search was performed in PubMed, Web of Science and Embase databases to identify eligible studies published in English. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated by random-effects models. Restricted cubic splines were used to assess the dose-response relationship. RESULTS: Eighteen studies were included in our meta-analysis. The pooled RR of periodontitis for the highest with the lowest alcohol consumption was 1.59 (95% CI: 1.37-1.85). Significant associations were also found in stratified analysis by gender [males: (1.25, 95% CI: 1.11-1.41), females (2.15, 95% CI: 1.36-3.41)] and study design [cohort studies: 1.28 (1.04-1.57) and cross-sectional studies: 1.66 (1.39-1.99)]. A linear dose-response relationship was found between alcohol consumption and periodontitis risk, and the risk of periodontitis increased by 0.4% [95% CI (1.002-1.007) (p = 0.002)] for each 1 g/day increment in alcohol consumption. CONCLUSION: This meta-analysis suggested that alcohol consumption was associated with an increased risk of periodontitis.
AIM: A meta-analysis was conducted to quantitatively summarize the evidence from observational studies on alcohol consumption and risk of periodontitis. MATERIAL AND METHODS: A comprehensive literature search was performed in PubMed, Web of Science and Embase databases to identify eligible studies published in English. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated by random-effects models. Restricted cubic splines were used to assess the dose-response relationship. RESULTS: Eighteen studies were included in our meta-analysis. The pooled RR of periodontitis for the highest with the lowest alcohol consumption was 1.59 (95% CI: 1.37-1.85). Significant associations were also found in stratified analysis by gender [males: (1.25, 95% CI: 1.11-1.41), females (2.15, 95% CI: 1.36-3.41)] and study design [cohort studies: 1.28 (1.04-1.57) and cross-sectional studies: 1.66 (1.39-1.99)]. A linear dose-response relationship was found between alcohol consumption and periodontitis risk, and the risk of periodontitis increased by 0.4% [95% CI (1.002-1.007) (p = 0.002)] for each 1 g/day increment in alcohol consumption. CONCLUSION: This meta-analysis suggested that alcohol consumption was associated with an increased risk of periodontitis.
Authors: Vanessa Machado; João Botelho; António Amaral; Luís Proença; Ricardo Alves; João Rua; Maria Alzira Cavacas; Ana Sintra Delgado; José João Mendes Journal: PeerJ Date: 2018-07-24 Impact factor: 2.984