Literature DB >> 27028695

Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.

William W Hay1, Laura D Brown1, Paul J Rozance1, Stephanie R Wesolowski1, Sean W Limesand2.   

Abstract

UNLABELLED: Previous attempts to improve growth and development of the intrauterine growth-restricted (IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies tissue-specific mechanisms underlying foetal growth restriction and then tests strategies to improve growth and ameliorate many of the metabolic problems before the infant is born. The goal of our studies is to reduce the impact of foetal growth restriction at critical stages of development on the lifelong complications of IUGR offspring.
CONCLUSION: Defining specific mechanisms that cause growth restriction in the foetus might identify specific nutrients and hormones that could be given to the mother to improve foetal growth and reduce metabolic complications, using strategies first tested in our IUGR animal model. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Amino acids; Glucose; Insulin; Intrauterine growth restriction; Oxygen

Mesh：

Substances：

Year:  2016        PMID： 27028695      PMCID： PMC5961494          DOI： 10.1111/apa.13413

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN： 0803-5253            Impact factor:   2.299


  63 in total

1.  Effects of chronic reduction in uterine blood flow on fetal and placental growth in the sheep.

Authors:  U Lang; R S Baker; J Khoury; K E Clark
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2000-07       Impact factor: 3.619

2.  Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.

Authors:  Sean W Limesand; Paul J Rozance; Danielle Smith; William W Hay
Journal:  Am J Physiol Endocrinol Metab       Date:  2007-09-25       Impact factor: 4.310

3.  Effects of increased cortisol concentration on ovine fetal leucine kinetics and protein metabolism.

Authors:  J R Milley
Journal:  Am J Physiol       Date:  1995-06

4.  Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.

Authors:  Sean W Limesand; Paul J Rozance; Gary O Zerbe; John C Hutton; William W Hay
Journal:  Endocrinology       Date:  2005-12-08       Impact factor: 4.736

5.  Effects of severe energy and protein deficiencies on the fibres and nuclei in skeletal muscle of pigs.

Authors:  N C Stickland; E M Widdowson; G Goldspink
Journal:  Br J Nutr       Date:  1975-11       Impact factor: 3.718

6.  Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep.

Authors:  Monika M Gadhia; Anne M Maliszewski; Meghan C O'Meara; Stephanie R Thorn; Jinny R Lavezzi; Sean W Limesand; William W Hay; Laura D Brown; Paul J Rozance
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-12-04       Impact factor: 4.310

7.  Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction.

Authors:  Laura D Brown; Paul J Rozance; Jennifer L Bruce; Jacob E Friedman; William W Hay; Stephanie R Wesolowski
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-07-29       Impact factor: 3.619

8.  Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance.

Authors:  Robert H Lane; Nicole K MacLennan; Jennifer L Hsu; Sara M Janke; Tho D Pham
Journal:  Endocrinology       Date:  2002-07       Impact factor: 4.736

9.  Uteroplacental carbon substrate metabolism and O2 consumption after long-term hypoglycemia in pregnant sheep.

Authors:  T D Carver; W W Hay
Journal:  Am J Physiol       Date:  1995-08

Review 10.  Endocrine regulation of fetal skeletal muscle growth: impact on future metabolic health.

Authors:  Laura D Brown
Journal:  J Endocrinol       Date:  2014-04-22       Impact factor: 4.286
View more
  12 in total

Review 1.  Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency.

Authors:  Sean W Limesand; Paul J Rozance
Journal:  J Physiol       Date:  2017-05-26       Impact factor: 5.182

Review 2.  Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology.

Authors:  Michael K Georgieff; Phu V Tran; Erik S Carlson
Journal:  Dev Psychopathol       Date:  2018-08

3.  Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates.

Authors:  Sandra G Wai; Paul J Rozance; Stephanie R Wesolowski; William W Hay; Laura D Brown
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-09-11       Impact factor: 4.310

4.  Sex Differences Across the Lifespan: A Focus on Cardiometabolism.

Authors:  T Rajendra Kumar; Jane E B Reusch; Wendy M Kohrt; Judith G Regensteiner
Journal:  J Womens Health (Larchmt)       Date:  2020-05-17       Impact factor: 2.681

5.  Effects of birth weight and dietary fat on intake, body composition, and plasma thyroxine in neonatal lambs.

Authors:  Jose M Ramos-Nieves; Sarah L Giesy; Molly M McGuckin; Yves R Boisclair
Journal:  J Anim Sci       Date:  2020-12-01       Impact factor: 3.159

6.  RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets.

Authors:  Amy C Kelly; Christopher A Bidwell; Fiona M McCarthy; David J Taska; Miranda J Anderson; Leticia E Camacho; Sean W Limesand
Journal:  Endocrinology       Date:  2017-04-01       Impact factor: 4.736

7.  Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep.

Authors:  Jane Stremming; Eileen I Chang; Leslie A Knaub; Michael L Armstrong; Peter R Baker; Stephanie R Wesolowski; Nichole Reisdorph; Jane E B Reusch; Laura D Brown
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2021-12-15       Impact factor: 3.619

8.  Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency.

Authors:  Laura D Brown; Claire Palmer; Lucas Teynor; Brit H Boehmer; Jane Stremming; Eileen I Chang; Alicia White; Amanda K Jones; Sarah N Cilvik; Stephanie R Wesolowski; Paul J Rozance
Journal:  Reprod Sci       Date:  2021-10-05       Impact factor: 2.924

9.  Treadmill Running of Mouse as a Model for Studying Influence of Maternal Exercise on Offspring.

Authors:  Song Ah Chae; Jun Seok Son; Mei-Jun Zhu; Jeanene M De Avila; And Min Du
Journal:  Bio Protoc       Date:  2020-12-05

10.  Real supermodels wear wool: summarizing the impact of the pregnant sheep as an animal model for adaptive fetal programming.

Authors:  Kristin A Beede; Sean W Limesand; Jessica L Petersen; Dustin T Yates
Journal:  Anim Front       Date:  2019-06-25
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.