Literature DB >> 27028424

Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters.

Yinghui Li1, Vinay Tergaonkar1,2,3.   

Abstract

Transcriptional activation of telomerase reverse transcriptase (TERT) gene is a rate-limiting determinant in the reactivation of telomerase expression in cancers. TERT promoter mutations represent one of the fundamental mechanisms of TERT reactivation in cancer development. We review recent studies that elucidate the molecular mechanisms underscoring activation of mutant TERT promoters.

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Year:  2016        PMID： 27028424      PMCID： PMC4853035          DOI： 10.1080/21541264.2016.1160173

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  31 in total

1.  Molecular biology. Wnt regulates TERT--putting the horse before the cart.

Authors:  Carol W Greider
Journal:  Science       Date:  2012-06-22       Impact factor: 47.728

2.  Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.

Authors:  Peter C Hollenhorst; Mary W Ferris; Megan A Hull; Heejoon Chae; Sun Kim; Barbara J Graves
Journal:  Genes Dev       Date:  2011-10-15       Impact factor: 11.361

Review 3.  Regulation of the human catalytic subunit of telomerase (hTERT).

Authors:  Michael Daniel; Gregory W Peek; Trygve O Tollefsbol
Journal:  Gene       Date:  2012-02-13       Impact factor: 3.688

Review 4.  Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene.

Authors:  Jiyue Zhu; Yuanjun Zhao; Shuwen Wang
Journal:  Protein Cell       Date:  2010-02-07       Impact factor: 14.870

5.  Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.

Authors:  C W Greider; E H Blackburn
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

6.  Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.

Authors:  Gong-Hong Wei; Gwenael Badis; Michael F Berger; Teemu Kivioja; Kimmo Palin; Martin Enge; Martin Bonke; Arttu Jolma; Markku Varjosalo; Andrew R Gehrke; Jian Yan; Shaheynoor Talukder; Mikko Turunen; Mikko Taipale; Hendrik G Stunnenberg; Esko Ukkonen; Timothy R Hughes; Martha L Bulyk; Jussi Taipale
Journal:  EMBO J       Date:  2010-06-01       Impact factor: 11.598

7.  Identification of Ets- and notch-related subunits in GA binding protein.

Authors:  K LaMarco; C C Thompson; B P Byers; E M Walton; S L McKnight
Journal:  Science       Date:  1991-08-16       Impact factor: 47.728

8.  Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.

Authors:  C C Thompson; T A Brown; S L McKnight
Journal:  Science       Date:  1991-08-16       Impact factor: 47.728

9.  Specific association of human telomerase activity with immortal cells and cancer.

Authors:  N W Kim; M A Piatyszek; K R Prowse; C B Harley; M D West; P L Ho; G M Coviello; W E Wright; S L Weinrich; J W Shay
Journal:  Science       Date:  1994-12-23       Impact factor: 47.728

Review 10.  Reactivation of telomerase in cancer.

Authors:  Semih Can Akincilar; Bilal Unal; Vinay Tergaonkar
Journal:  Cell Mol Life Sci       Date:  2016-02-04       Impact factor: 9.261
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  14 in total

1.  Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.

Authors:  Yinghui Li; Hui Shan Cheng; Wee Joo Chng; Vinay Tergaonkar
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-23       Impact factor: 11.205

Review 2.  Genetic alterations in hepatocellular carcinoma: An update.

Authors:  Zhao-Shan Niu; Xiao-Jun Niu; Wen-Hong Wang
Journal:  World J Gastroenterol       Date:  2016-11-07       Impact factor: 5.742

3.  Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia.

Authors:  Yan Xiu; Qianze Dong; Qingchang Li; Fengyin Li; Nick Borcherding; Weizhou Zhang; Brendan Boyce; Hai-Hui Xue; Chen Zhao
Journal:  Cell Rep       Date:  2018-01-09       Impact factor: 9.423

Review 4.  Current Insights to Regulation and Role of Telomerase in Human Diseases.

Authors:  Mert Burak Ozturk; Yinghui Li; Vinay Tergaonkar
Journal:  Antioxidants (Basel)       Date:  2017-02-28

Review 5.  Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC.

Authors:  Ekta Khattar; Vinay Tergaonkar
Journal:  Front Cell Dev Biol       Date:  2017-01-26

6.  Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer.

Authors:  Federica Panebianco; Alyaksandr V Nikitski; Marina N Nikiforova; Yuri E Nikiforov
Journal:  Cancer Med       Date:  2019-08-13       Impact factor: 4.452

7.  Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction.

Authors:  Shalu Sharma; Ananda Kishore Mukherjee; Shuvra Shekhar Roy; Sulochana Bagri; Silje Lier; Meenakshi Verma; Antara Sengupta; Manish Kumar; Gaute Nesse; Deo Prakash Pandey; Shantanu Chowdhury
Journal:  Cell Rep       Date:  2021-05-18       Impact factor: 9.423

Review 8.  Telomere Length Dynamics and the Evolution of Cancer Genome Architecture.

Authors:  Kez Cleal; Kevin Norris; Duncan Baird
Journal:  Int J Mol Sci       Date:  2018-02-06       Impact factor: 5.923

Review 9.  Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy.

Authors:  Paola M Dantonio; Marianne O Klein; Maria Renata V B Freire; Camila N Araujo; Ana Carolina Chiacetti; Ricardo G Correa
Journal:  Biosci Rep       Date:  2018-10-02       Impact factor: 3.840

Review 10.  Integrating the DNA damage and protein stress responses during cancer development and treatment.

Authors:  Vassilis G Gorgoulis; Dafni-Eleftheria Pefani; Ioannis S Pateras; Ioannis P Trougakos
Journal:  J Pathol       Date:  2018-07-19       Impact factor: 7.996
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