Literature DB >> 27028280

Common scientific and statistical errors in obesity research.

Brandon J George1, T Mark Beasley2, Andrew W Brown1,3, John Dawson4, Rositsa Dimova5, Jasmin Divers6, TaShauna U Goldsby1,3, Moonseong Heo7, Kathryn A Kaiser1,3, Scott W Keith8, Mimi Y Kim7, Peng Li1,2, Tapan Mehta3,9, J Michael Oakes10, Asheley Skinner11, Elizabeth Stuart12, David B Allison1,2,3.   

Abstract

This review identifies 10 common errors and problems in the statistical analysis, design, interpretation, and reporting of obesity research and discuss how they can be avoided. The 10 topics are: 1) misinterpretation of statistical significance, 2) inappropriate testing against baseline values, 3) excessive and undisclosed multiple testing and "P-value hacking," 4) mishandling of clustering in cluster randomized trials, 5) misconceptions about nonparametric tests, 6) mishandling of missing data, 7) miscalculation of effect sizes, 8) ignoring regression to the mean, 9) ignoring confirmation bias, and 10) insufficient statistical reporting. It is hoped that discussion of these errors can improve the quality of obesity research by helping researchers to implement proper statistical practice and to know when to seek the help of a statistician.
© 2016 The Obesity Society.

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Year:  2016        PMID: 27028280      PMCID: PMC4817356          DOI: 10.1002/oby.21449

Source DB:  PubMed          Journal:  Obesity (Silver Spring)        ISSN: 1930-7381            Impact factor:   5.002


  63 in total

Review 1.  Selected statistical issues in group randomized trials.

Authors:  Z Feng; P Diehr; A Peterson; D McLerran
Journal:  Annu Rev Public Health       Date:  2001       Impact factor: 21.981

Review 2.  Longitudinal data analysis (repeated measures) in clinical trials.

Authors:  P S Albert
Journal:  Stat Med       Date:  1999-07-15       Impact factor: 2.373

3.  Data extraction errors in meta-analyses that use standardized mean differences.

Authors:  Peter C Gøtzsche; Asbjørn Hróbjartsson; Katja Maric; Britta Tendal
Journal:  JAMA       Date:  2007-07-25       Impact factor: 56.272

4.  Belief beyond the evidence: using the proposed effect of breakfast on obesity to show 2 practices that distort scientific evidence.

Authors:  Andrew W Brown; Michelle M Bohan Brown; David B Allison
Journal:  Am J Clin Nutr       Date:  2013-09-04       Impact factor: 7.045

5.  Interpreting estimates of treatment effects: implications for managed care.

Authors:  Stephen V Faraone
Journal:  P T       Date:  2008-12

6.  Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.

Authors:  Aram V Chobanian; George L Bakris; Henry R Black; William C Cushman; Lee A Green; Joseph L Izzo; Daniel W Jones; Barry J Materson; Suzanne Oparil; Jackson T Wright; Edward J Roccella
Journal:  Hypertension       Date:  2003-12-01       Impact factor: 10.190

7.  Effect sizes for growth-modeling analysis for controlled clinical trials in the same metric as for classical analysis.

Authors:  Alan Feingold
Journal:  Psychol Methods       Date:  2009-03

8.  Evaluation of a multicomponent intervention to improve weight status and fitness in children: Upstarts.

Authors:  Gavin R H Sandercock; Daniel D Cohen; Murray Griffin
Journal:  Pediatr Int       Date:  2012-11-21       Impact factor: 1.524

9.  Unintended consequences of obesity-targeted health policy.

Authors:  Andrew W Brown; David B Allison
Journal:  Virtual Mentor       Date:  2013-04-01

10.  The extent and consequences of p-hacking in science.

Authors:  Megan L Head; Luke Holman; Rob Lanfear; Andrew T Kahn; Michael D Jennions
Journal:  PLoS Biol       Date:  2015-03-13       Impact factor: 8.029

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  34 in total

1.  Differences in Nominal Significance (DINS) Error leads to invalid conclusions: Letter regarding, "Diet enriched with fresh coconut decreases blood glucose levels and body weight in normal adults".

Authors:  Cynthia M Kroeger; Andrew W Brown; David B Allison
Journal:  J Complement Integr Med       Date:  2019-06-12

2.  Best (but oft-forgotten) practices: mediation analysis.

Authors:  Amanda J Fairchild; Heather L McDaniel
Journal:  Am J Clin Nutr       Date:  2017-04-26       Impact factor: 7.045

3.  The stated conclusions are contradicted by the data, based on inappropriate statistics, and should be corrected: comment on 'intervention for childhood obesity based on parents only or parents and child compared with follow-up alone'.

Authors:  J A Dawson; A W Brown; D B Allison
Journal:  Pediatr Obes       Date:  2018-08-09       Impact factor: 4.000

4.  Incorrect analyses were used in "Different enteral nutrition formulas have no effect on glucose homeostasis but on diet-induced thermogenesis in critically ill medical patients: a randomized controlled trial" and corrected analyses are requested.

Authors:  Stephanie L Dickinson; Andrew W Brown; Tapan Mehta; Steven B Heymsfield; Cara B Ebbeling; David S Ludwig; David B Allison
Journal:  Eur J Clin Nutr       Date:  2018-06-27       Impact factor: 4.016

5.  Scientific rigor and credibility in the nutrition research landscape.

Authors:  Cynthia M Kroeger; Cutberto Garza; Christopher J Lynch; Esther Myers; Sylvia Rowe; Barbara O Schneeman; Arya M Sharma; David B Allison
Journal:  Am J Clin Nutr       Date:  2018-03-01       Impact factor: 7.045

6.  Issues with data and analyses: Errors, underlying themes, and potential solutions.

Authors:  Andrew W Brown; Kathryn A Kaiser; David B Allison
Journal:  Proc Natl Acad Sci U S A       Date:  2018-03-13       Impact factor: 11.205

7.  Regression to the mean, apparent data errors and biologically extraordinary results: letter regarding 'changes in telomere length 3-5 years after gastric bypass surgery'.

Authors:  D L Smith; D M Thomas; C O Siu; S Verhulst; D B Allison
Journal:  Int J Obes (Lond)       Date:  2017-12-12       Impact factor: 5.095

8.  Drawing conclusions from within-group comparisons and selected subsets of data leads to unsubstantiated conclusions: Letter regarding Malakellis et al.

Authors:  Bryan McComb; Alexis C Frazier-Wood; John Dawson; David B Allison
Journal:  Aust N Z J Public Health       Date:  2017-12-27       Impact factor: 2.939

9.  Best (but oft-forgotten) practices: identifying and accounting for regression to the mean in nutrition and obesity research.

Authors:  Diana M Thomas; Nicholas Clark; Dusty Turner; Cynthia Siu; Tanya M Halliday; Bridget A Hannon; Chanaka N Kahathuduwa; Cynthia M Kroeger; Roger Zoh; David B Allison
Journal:  Am J Clin Nutr       Date:  2020-02-01       Impact factor: 7.045

Review 10.  Top ten errors of statistical analysis in observational studies for cancer research.

Authors:  A Carmona-Bayonas; P Jimenez-Fonseca; A Fernández-Somoano; F Álvarez-Manceñido; E Castañón; A Custodio; F A de la Peña; R M Payo; L P Valiente
Journal:  Clin Transl Oncol       Date:  2017-12-07       Impact factor: 3.405

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