Ajay Kundra1, Mirela Andrei1, William Westra2, Rashid Chaudhry3, Harry Moussouris4, Arash Gohari5, Jen C Wang1. 1. Division of Hematology and Oncology, Brookdale University Hospital and Medical Center, Brooklyn, New York. 2. Division of Pathology, Oncology, and Otolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland. 3. Division of Otolaryngology/Head and Neck Surgery, Brookdale University Hospital and Medical Center, Brooklyn, New York. 4. Division of Pathology, Brookdale University Hospital and Medical Center, Brooklyn, New York. 5. Division of Radiology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
Abstract
BACKGROUND: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. METHODS AND RESULTS: The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune-stain positivity conclusively established the diagnosis of NUT midline carcinoma. CONCLUSION: Absence of well-known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis.
BACKGROUND: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. METHODS AND RESULTS: The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune-stain positivity conclusively established the diagnosis of NUT midline carcinoma. CONCLUSION: Absence of well-known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis.
Authors: Henrik Hellquist; Christopher A French; Justin A Bishop; Andrés Coca-Pelaz; Evan J Propst; António Paiva Correia; Bo-Yee Ngan; Ronald Grant; Nicole A Cipriani; David Vokes; Rui Henrique; Fernando Pardal; Jose Ramon Vizcaino; Alessandra Rinaldo; Alfio Ferlito Journal: Histopathology Date: 2017-02-21 Impact factor: 5.087