CONTEXT: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD). OBJECTIVES: To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury. MATERIAL AND METHODS: Human L-FABP chromosomal transgenic (Tg) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20 min or 30 min. Kidneys were obtained at one and 40 days after I/R. RESULTS: Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. DISCUSSION AND CONCLUSION: These markers could detect higher risk of progression to CKD.
CONTEXT: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD). OBJECTIVES: To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury. MATERIAL AND METHODS:HumanL-FABP chromosomal transgenic (Tg) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20 min or 30 min. Kidneys were obtained at one and 40 days after I/R. RESULTS: Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. DISCUSSION AND CONCLUSION: These markers could detect higher risk of progression to CKD.
Entities:
Keywords:
AKI to CKD transition; Acute kidney injury; chronic kidney disease; renal damage
Authors: Adriano César Carneiro Loureiro; Gabriella Fontenele Nocrato; André Luis Lima Correia; Robson Salviano de Matos; Júlio César Chaves Nunes Filho; Elisabeth De Francesco Daher; Flávio Henrique Macedo Pinto; Ariclécio Cunha de Oliveira; Vania Marilande Ceccatto; Rodrigo Soares Fortunato; Denise Pires de Carvalho Journal: Front Physiol Date: 2022-03-17 Impact factor: 4.566
Authors: Sadudee Peerapornratana; Priyanka Priyanka; Shu Wang; Ali Smith; Kai Singbartl; Paul M Palevsky; Lakhmir S Chawla; Donald M Yealy; Derek C Angus; John A Kellum Journal: Kidney Int Rep Date: 2020-03-12