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Literature DB >> 27027552

GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line.

Maryam Bikhof Torbati¹, Masoud Ebrahimian², Mohammad Yousefi², Masoud Shaabanzadeh³.

Abstract

The graphene oxide nanosheets can act as a nanocarrier for the delivery of therapeutic agents. The PEGylated GO has high solubility, good stability, and more biocompatibility in physiological solutions. In this study, the anticancer effects of synthesized GO-PEG as a drug nanocarrier evaluated to estimate the synergistic cytotoxic effect of drugs loaded on this type of nanocarrier and to determine the actual effect of any drugs encapsulated on it. The cytotoxic effects of GO-PEG nanosheets were evaluated on HeLa cell line by MTT assay. The results exhibited cytotoxic property of PEGylated GO drug nanocarrier significantly is dose dependent and incubation time dependent.

Entities: Chemical Disease Species

Keywords: Anticancer; MTT assay; PEGylated; graphene oxide; nanocarrier

Mesh：

Substances：

Year: 2016 PMID： 27027552 DOI： 10.3109/21691401.2016.1161641

Source DB: PubMed Journal: Artif Cells Nanomed Biotechnol ISSN： 2169-1401 Impact factor: 5.678

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Cited

3 in total

1. Hydroxyurea-loaded Fe₃O₄/SiO₂/chitosan-g-mPEG2000 nanoparticles; pH-dependent drug release and evaluation of cell cycle arrest and altering p53 and lincRNA-p21 genes expression.

Authors: Mahsa Moeini Chaghervand; Maryam Bikhof Torbati; Masoud Shaabanzadeh; Adeleh Ahmadi; Farzaneh Tafvizi
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2021-10-18 Impact factor: 3.000

2. The Value and Clinical Significance of ZNF582 Gene Methylation in the Diagnosis of Cervical Cancer.

Authors: Chunhe Zhang; Shaowei Fu; Luyue Wang; Fang Wang; Dan Wu; Xiangyi Zhe; Huizhen Xin; Hongtao Li; Dongmei Li; Fuyuan Jin; Renfu Shao; Zemin Pan
Journal: Onco Targets Ther Date: 2021-01-14 Impact factor: 4.147

3. Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake.

Authors: Anna Aviñó; Anna Clua; Maria José Bleda; Ramon Eritja; Carme Fàbrega
Journal: Int J Mol Sci Date: 2021-05-26 Impact factor: 5.923

3 in total

GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line.

1. Hydroxyurea-loaded Fe3O4/SiO2/chitosan-g-mPEG2000 nanoparticles; pH-dependent drug release and evaluation of cell cycle arrest and altering p53 and lincRNA-p21 genes expression.

2. The Value and Clinical Significance of ZNF582 Gene Methylation in the Diagnosis of Cervical Cancer.

3. Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake.

1. Hydroxyurea-loaded Fe₃O₄/SiO₂/chitosan-g-mPEG2000 nanoparticles; pH-dependent drug release and evaluation of cell cycle arrest and altering p53 and lincRNA-p21 genes expression.