Literature DB >> 27027486

The ever-expanding role of HIF in tumour and stromal biology.

Edward L LaGory1, Amato J Giaccia1.   

Abstract

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.

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Year:  2016        PMID： 27027486      PMCID： PMC4898054          DOI： 10.1038/ncb3330

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  150 in total

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