Literature DB >> 27027105

Rational design of multifunctional small-molecule prodrugs for simultaneous suppression of cancer cell growth and metastasis in vitro and in vivo.

Haiyang Xie1, Xiao Xu1, Jianmei Chen1, Lingling Li1, Jianguo Wang1, Tao Fang2, Lin Zhou1, Hangxiang Wang1, Shusen Zheng1.   

Abstract

We present a design concept for multifunctional prodrugs that simultaneously induce apoptosis and suppress cancer cell metastasis in vitro and in vivo. These "all-in-one" prodrug constructs possess therapeutic potential as novel "integrative" platforms for metastatic cancer treatment.

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Year:  2016        PMID： 27027105     DOI： 10.1039/c5cc10367c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  A novel oncolytic adenovirus inhibits hepatocellular carcinoma growth.

Authors:  Yu-Huan Bai; Xiao-Jing Yun; Yan Xue; Ting Zhou; Xin Sun; Yan-Jing Gao
Journal:  J Zhejiang Univ Sci B       Date:  2019 Dec.       Impact factor: 3.066

2.  The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro.

Authors:  Chang K Zhao; Chan Li; Xian H Wang; Yu J Bao; Fu H Yang; Mei Huang
Journal:  R Soc Open Sci       Date:  2018-06-13       Impact factor: 2.963

3.  Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations.

Authors:  Hangxiang Wang; Jianmei Chen; Chang Xu; Linlin Shi; Munire Tayier; Jiahui Zhou; Jun Zhang; Jiaping Wu; Zhijian Ye; Tao Fang; Weidong Han
Journal:  Theranostics       Date:  2017-08-23       Impact factor: 11.556
  3 in total

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