Treatment of glioma with intratumoral instillation of autologous lymphocytes.

Autologous lymphocytes were instilled into the tumor in a girl 15 years of age who had presented with a recurrent left frontoparietal astrocytoma 1.5 years after surgery, radiation, and chemotherapy. She had remissions for 5 weeks, 5 months, and 20 months after the first, second, and third instillations, respectively. The usefulness of intratumoral instillation of autologous lymphocytes [or preferably lymphokine activated killer (LAK) cells with interleukin-2 is demonstrated in such recurrent astrocytomas.