Sunil Agarwal 1 , Jonathan Mark 2 , Changchun Xie 3 , Enas Ghulam 4 , Yash Patil 2 Show Affiliations »
Abstract
OBJECTIVE: Determine survival and factors affecting survival for patients with malignant tumors of odontogenic origin. STUDY DESIGN: Retrospective analysis of the National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results). SETTING: Tertiary medical center. SUBJECTS AND METHODS: All cases of malignant tumors of odontogenic origin were extracted from the SEER database for the period of 1973 to 2011. Demographic, tumor-specific, and survival data were tabulated and Kaplan-Meier survival analysis conducted according to histopathologic results. Cox regression analysis stratified for histopathology was conducted to determine factors that influenced survival. RESULTS: A total of 308 cases of malignant tumors with odontogenic origin were analyzed. Malignant ameloblastoma accounted for 59.7% of cases, followed by malignant odontogenic tumor (35.4%; including odontogenic carcinoma, odontogenic sarcoma, primary intraosseous carcinoma, and ameloblastic carcinoma) and ameloblastic fibrosarcoma (2.9%). The overall mean and median were 229 and 227 months, respectively, while the 5-year survival rate was 81% for the entire cohort. Malignant ameloblastoma exhibited the best mean survival (237 months), whereas malignant odontogenic tumor (139 months) and ameloblastic fibrosarcoma (42 months) had lower mean survival rates. Younger age, surgery with adjuvant radiation, and smaller tumor size were found to improve survival. CONCLUSIONS: Significantly different survival can be expected depending on individual tumor histopathology, tumor size, age at diagnosis, and treatment modality. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.
OBJECTIVE: Determine survival and factors affecting survival for patients with malignant tumors of odontogenic origin. STUDY DESIGN: Retrospective analysis of the National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results). SETTING: Tertiary medical center. SUBJECTS AND METHODS: All cases of malignant tumors of odontogenic origin were extracted from the SEER database for the period of 1973 to 2011. Demographic, tumor -specific, and survival data were tabulated and Kaplan-Meier survival analysis conducted according to histopathologic results. Cox regression analysis stratified for histopathology was conducted to determine factors that influenced survival. RESULTS: A total of 308 cases of malignant tumors with odontogenic origin were analyzed. Malignant ameloblastoma accounted for 59.7% of cases, followed by malignant odontogenic tumor (35.4%; including odontogenic carcinoma , odontogenic sarcoma , primary intraosseous carcinoma , and ameloblastic carcinoma ) and ameloblastic fibrosarcoma (2.9%). The overall mean and median were 229 and 227 months, respectively, while the 5-year survival rate was 81% for the entire cohort. Malignant ameloblastoma exhibited the best mean survival (237 months), whereas malignant odontogenic tumor (139 months) and ameloblastic fibrosarcoma (42 months) had lower mean survival rates. Younger age, surgery with adjuvant radiation, and smaller tumor size were found to improve survival. CONCLUSIONS: Significantly different survival can be expected depending on individual tumor histopathology, tumor size, age at diagnosis, and treatment modality. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.
Entities: Disease
Species
Keywords:
ameloblastic fibrosarcoma; malignant ameloblastoma; malignant odontogenic tumor
Mesh： See more »
Year: 2016
PMID： 27026731 DOI： 10.1177/0194599816639540
Source DB: PubMed Journal: Otolaryngol Head Neck Surg ISSN： 0194-5998 Impact factor: 3.497