| Literature DB >> 27026488 |
Jie Zeng1, Lu-Ying Cui1, Yan Feng1, Ming-Xing Ding2.
Abstract
Glutamate transports (GTs), the only vehicle for removal of glutamate from the extracellular fluid, is reported to be related to chronic pain. To investigate whether the glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) participate in electroacupuncture (EA) analgesia, the EA effect was observed with paw withdraw threshold in a rat model of spared nerve injury. The expression levels of GLAST and GLT-1 were determined with Western Blot and RT-PCR. The results showed significantly upregulated GLAST and GLT-1, along with the relieved pain behaviors after EA treatment. In addition, intrathecal injection of GTs inhibitor, l-trans-pyrrolidine-2-4-dicarboxylate, attenuated the EA-induced analgesic effect. The experiment demonstrates that EA can increase the GTs of neuropathic pain rats, which might be one of the mechanisms underlying its effectiveness in the neuropathic pain.Entities:
Keywords: Electroacupuncture; GLAST; GLT-1; Neuropathic pain; l-trans-Pyrrolidine-2-4-dicarboxylate
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Year: 2016 PMID： 27026488 DOI： 10.1016/j.neulet.2016.03.041
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046