Literature DB >> 27025494

Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide.

T N Shelykh1, I V Rogachevsky2, A D Nozdrachev2, O S Veselkina2, S A Podzorova2, B V Krylov2, V B Plakhova2.   

Abstract

Using the whole-cell patch-clamp method, the ability of arginine-containing tripeptide Ac-RER-NH2, dipeptide Ac-RR-NH2, and free Arg molecule to modulate the membrane excitability of nociceptors was studied. Extracellular Ac-RER-NH2 upon interaction with the outer membrane of the nociceptive neuron decreases the Zeff value of the activation gating system of Nav1.8 channels. Thus, the tripeptide Ac-RER-NH2 can be considered as a new effective and safe analgesic.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27025494     DOI： 10.1134/S1607672916010191

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  9 in total

1.  [Putative molecular mechanism of defensin interaction with the membrane of the sensory neuron].

Authors:  V B PLakhova; B F Shchegolev; I V Rogachevskiĭ; A D Nozdrachev; B V Krylov; S A Podzorova; V N Kokriakov
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  2000-11

2.  The defensin receptor: a possible mechanism responsible for reduced excitability of the neuronal sensory membrane.

Authors:  I V Rogachevskii; V B Plakhova; B F Shchegolev; A D Nozdrachev; B V Krylov; S A Podzorova; V N Kokryakov
Journal:  Dokl Biol Sci       Date:  2000 Nov-Dec

3.  Effect of internal fluoride and phosphate on membrane currents during intracellular dialysis of nerve cells.

Authors:  P G Kostyuk; O A Krishtal; V I Pidoplichko
Journal:  Nature       Date:  1975-10-23       Impact factor: 49.962

4.  Mechanism of pain relief by low-power infrared irradiation: ATP is an IR-target molecule in nociceptive neurons.

Authors:  Igor L Yachnev; Vera B Plakhova; Svetlana A Podzorova; Tatiana N Shelykh; Ilya V Rogachevsky; Boris V Krylov
Journal:  Med Chem       Date:  2012-01       Impact factor: 2.745

5.  [Endogenous defensin antibiotics as tentative regulators of sodium channels in spinal ganglion neurons].

Authors:  A D Nozdrachev; B V Krylov; V S Sabanov; S A Podzorova; V B Plakhova; O V Shamova; D S Orlov; V N Kokriakov
Journal:  Dokl Akad Nauk       Date:  1997-08

6.  5HT4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons.

Authors:  C G Cardenas; L P Del Mar; B Y Cooper; R S Scroggs
Journal:  J Neurosci       Date:  1997-10-01       Impact factor: 6.167

7.  Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-I. Sodium currents.

Authors:  P G Kostyuk; N S Veselovsky; A Y Tsyndrenko
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

8.  [Kinetics of sodium current decay during normal axon membrane repolarization and in the presence of scorpion toxin].

Authors:  G N Mozhaeva; A P Naumov; E D Nosyreva
Journal:  Neirofiziologiia       Date:  1980

9.  [Morphine decreases the voltage sensitivity of the slow sodium channels].

Authors:  B V Krylov; A V Derbenev; S A Podzorova; M I Liudyno; A V Kuz'min; N L Izvarina
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  1999-02
  9 in total
  1 in total

1.  Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel.

Authors:  Ilya V Rogachevskii; Vera B Plakhova; Valentina A Penniyaynen; Arina D Kalinina; Svetlana A Podzorova; Dmitriy M Samosvat; Georgy G Zegrya; Boris V Krylov
Journal:  Int J Mol Sci       Date:  2022-05-26       Impact factor: 6.208
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.