| Literature DB >> 27025482 |
M A Rosenfeld1, V B Leonova2, A V Bychkova2, E A Kostanova2, M I Biryukova2, N B Sultimova2, M L Konstantinova2, M G Gorobets2.
Abstract
The effect on ozone-induced oxidation on the self-assembly of fibrin in the presence of fibrin-stabilizing factor FXIIIa of soluble cross-linked fibrin oligomers was studied in a medium containing moderate urea concentrations. It is established that fibrin oligomers were formed by the protofibrils cross-linked through γ-γ dimers and the fibrils additionally cross-linked by through α-polymers. The oxidation promoted both the accumulation of greater amounts of γ-γ dimers and the formation of protofibrils, fibrils, and their dissociation products emerging with increasing urea concentrations, which have a high molecular weight. It is concluded that the oxidation enhances the axial interactions between D-regions of fibrin molecules.Entities:
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Year: 2016 PMID： 27025482 DOI： 10.1134/S1607672916010087
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788