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Literature DB >> 27025476

Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster.

A K Golovnin¹, M V Kostyuchenko², P G Georgiev², L S Melnikova².

Abstract

As a result of experiments in yeast two-hybrid system, coimmunoprecipitation of proteins from D. melanogaster embryo cell lysate, and immunostaining, it was shown for the first time that Mod(mdg4)-58.8 protein (isoform P), a product of mod(mdg4) locus, directly interacts with mtACP1A and mtACP1B proteins. These proteins are involved in de novo biosynthesis of fatty acids in mitochondria and are required for normal gametogenesis in males and females and, possibly, for the trachea development. This result expands the understanding of the role of mod(mdg4) locus products in the regulation of life activity of the eukaryotic cell.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2016 PMID： 27025476 DOI： 10.1134/S1607672916010026

Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788

15 in total

1. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.

Authors: A Melnick; K F Ahmad; S Arai; A Polinger; H Ball; K L Borden; G W Carlile; G G Prive; J D Licht
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

2. Experimental evidence for the influence of molecular crowding on nuclear architecture.

Authors: Karsten Richter; Michelle Nessling; Peter Lichter
Journal: J Cell Sci Date: 2007-04-12 Impact factor: 5.285

3. Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.

Authors: P Georgiev; M Kozycina
Journal: Genetics Date: 1996-02 Impact factor: 4.562

4. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology.

Authors: K R Katsani; M A Hajibagheri; C P Verrijzer
Journal: EMBO J Date: 1999-02-01 Impact factor: 11.598

5. SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.

Authors: Anton Golovnin; Ilya Volkov; Pavel Georgiev
Journal: J Cell Sci Date: 2012-02-28 Impact factor: 5.285

6. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins.

Authors: M Gause; P Morcillo; D Dorsett
Journal: Mol Cell Biol Date: 2001-07 Impact factor: 4.272

2. Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.

Authors: Larisa Melnikova; Margarita Kostyuchenko; Varvara Molodina; Alexander Parshikov; Pavel Georgiev; Anton Golovnin
Journal: Open Biol Date: 2017-10 Impact factor: 6.411

2 in total

Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster.

1. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.

2. Experimental evidence for the influence of molecular crowding on nuclear architecture.

3. Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.

4. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology.

5. SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation.

6. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins.

7. Integrity of the Mod(mdg4)-67.2 BTB domain is critical to insulator function in Drosophila melanogaster.

8. Brahma regulates a specific trans-splicing event at the mod(mdg4) locus of Drosophila melanogaster.

Review 9. The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.

10. A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila.

1. Effects of CASZI on bronchopulmonary development of neonatal rats.

2. Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.