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Literature DB >> 27025259

New strategies against drug resistance to herpes simplex virus.

Yu-Chen Jiang¹, Hui Feng², Yu-Chun Lin¹, Xiu-Rong Guo^3,4.

Abstract

Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2016 PMID： 27025259 PMCID： PMC4822185 DOI： 10.1038/ijos.2016.3

Source DB: PubMed Journal: Int J Oral Sci ISSN： 1674-2818 Impact factor: 6.344

103 in total

Review 1. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

Authors: Jocelyne Piret; Guy Boivin
Journal: Antimicrob Agents Chemother Date: 2010-11-15 Impact factor: 5.191

Review 2. The discovery of antiviral agents: ten different compounds, ten different stories.

Authors: Erik De Clercq
Journal: Med Res Rev Date: 2008-11 Impact factor: 12.944

Review 3. Ribavirin's antiviral mechanism of action: lethal mutagenesis?

Authors: Shane Crotty; Craig Cameron; Raul Andino
Journal: J Mol Med (Berl) Date: 2001-12-04 Impact factor: 4.599

4. Synthesis of Janus type nucleoside analogues and their preliminary bioactivity.

Authors: Hao-Zhe Yang; Mei-Ying Pan; Da-Wei Jiang; Yang He
Journal: Org Biomol Chem Date: 2011-01-12 Impact factor: 3.876

Review 5. A 40-year journey in search of selective antiviral chemotherapy.

Authors: Erik De Clercq
Journal: Annu Rev Pharmacol Toxicol Date: 2011 Impact factor: 13.820

Review 6. Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms.

Authors: Christian Gilbert; Julie Bestman-Smith; Guy Boivin
Journal: Drug Resist Updat Date: 2002-04 Impact factor: 18.500

7. Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.

Authors: Andrew H Karaba; Laura K Cohen; Taly Glaubach; Sarah J Kopp; Jennifer L Reichek; Hawke H Yoon; Xiaotian T Zheng; William J Muller
Journal: J Pediatric Infect Dis Soc Date: 2012-05-03 Impact factor: 3.164

8. Human herpesvirus 6 major immediate early promoter has strong activity in T cells and is useful for heterologous gene expression.

Authors: Masaaki Matsuura; Masaya Takemoto; Koichi Yamanishi; Yasuko Mori
Journal: Virol J Date: 2011-01-11 Impact factor: 4.099

9. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy.

Authors: Miftahul Akhyar Latief; Taiichiro Chikama; Ji-Ae Ko; Yoshiaki Kiuchi; Takemasa Sakaguchi; Akira Obana
Journal: Mol Vis Date: 2015-05-02 Impact factor: 2.367

10. Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.

Authors: Kareem N Mohni; Samantha Smith; Alexander R Dee; April J Schumacher; Sandra K Weller
Journal: PLoS Pathog Date: 2013-10-03 Impact factor: 6.823

45 in total

1. In Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection.

Authors: James Hopkins; Tejabhiram Yadavalli; Rahul Suryawanshi; Farreh Qatanani; Ipsita Volety; Ram Koganti; Aqsa Iqbal; Deepak Shukla
Journal: Antimicrob Agents Chemother Date: 2020-08-20 Impact factor: 5.191

2. Interventions to Improve Antimicrobial Stewardship for Older People in Care Homes: A Systematic Review.

Authors: Hoa Q Nguyen; Michael M Tunney; Carmel M Hughes
Journal: Drugs Aging Date: 2019-04 Impact factor: 3.923

3. Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye.

Authors: Tejabhiram Yadavalli; Rahul Suryawanshi; Marwan Ali; Aqsa Iqbal; Raghuram Koganti; Joshua Ames; Vinay Kumar Aakalu; Deepak Shukla
Journal: Ocul Surf Date: 2019-11-23 Impact factor: 5.033

Review 4. Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea.

Authors: Lulia Koujah; Rahul K Suryawanshi; Deepak Shukla
Journal: Cell Mol Life Sci Date: 2018-10-16 Impact factor: 9.261

5. Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an In Vitro High-Throughput Screening Assay.

Authors: Thibaut Deschamps; Hope Waisner; Christos Dogrammatzis; Anuradha Roy; Shibin Chacko; Chamani Perera; Thomas E Prisinzano; Maria Kalamvoki
Journal: J Virol Date: 2019-06-14 Impact factor: 5.103