PURPOSE: Colon cancers in male and female patients are suggested to be oncologically different. The aim of this study is to elucidate the prognostic impact of lymph node dissection (LND) in male and female colon cancer patients. METHODS: A total of 5941 stage I-III colon cancer patients who were curatively operated on during the period from 1997 to 2007 were retrospectively studied. Cancer-specific survival (CSS) was individually compared between for male and female patients treated with D3, D2, and D1 LND. Background differences of the patients were matched using propensity scores. RESULTS: D3, D2, and D1 LND were performed in 3756 (63 %), 1707 (29 %), and 478 (8 %), respectively, and more extensive LND was indicated for younger patients and more advanced disease. D2 LND was significantly associated with decreased cancer-specific mortality compared to D1 LND in male patients (HR 0.54, 95 % CI 0.32-0.89, p = 0.04), but not in female patients. D3 LND did not correlate to an improved prognosis compared to D2 LND both in male and female patients. CONCLUSIONS: D2 LND was associated with an improved CSS in male, but not female colon cancer patients, compared to D1 LND. This suggested that colon cancer in male and female patients might be oncologically different, and that the prognostic impact of the extent of surgical intervention for colon cancer might therefore be different between sexes.
PURPOSE:Colon cancers in male and female patients are suggested to be oncologically different. The aim of this study is to elucidate the prognostic impact of lymph node dissection (LND) in male and female colon cancerpatients. METHODS: A total of 5941 stage I-III colon cancerpatients who were curatively operated on during the period from 1997 to 2007 were retrospectively studied. Cancer-specific survival (CSS) was individually compared between for male and female patients treated with D3, D2, and D1 LND. Background differences of the patients were matched using propensity scores. RESULTS: D3, D2, and D1 LND were performed in 3756 (63 %), 1707 (29 %), and 478 (8 %), respectively, and more extensive LND was indicated for younger patients and more advanced disease. D2 LND was significantly associated with decreased cancer-specific mortality compared to D1 LND in male patients (HR 0.54, 95 % CI 0.32-0.89, p = 0.04), but not in female patients. D3 LND did not correlate to an improved prognosis compared to D2 LND both in male and female patients. CONCLUSIONS: D2 LND was associated with an improved CSS in male, but not female colon cancerpatients, compared to D1 LND. This suggested that colon cancer in male and female patients might be oncologically different, and that the prognostic impact of the extent of surgical intervention for colon cancer might therefore be different between sexes.
Entities:
Keywords:
Colon cancer; Lymph node dissection; Prognosis; Surgery
Authors: Nicholas P West; Werner Hohenberger; Klaus Weber; Aristoteles Perrakis; Paul J Finan; Philip Quirke Journal: J Clin Oncol Date: 2009-11-30 Impact factor: 44.544
Authors: Tess V Clendenen; Karen L Koenig; Roy E Shore; Mortimer Levitz; Alan A Arslan; Anne Zeleniuch-Jacquotte Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-01 Impact factor: 4.254
Authors: Ondrej Majek; Adam Gondos; Lina Jansen; Katharina Emrich; Bernd Holleczek; Alexander Katalinic; Alice Nennecke; Andrea Eberle; Hermann Brenner Journal: PLoS One Date: 2013-07-05 Impact factor: 3.240
Authors: Tamara Díaz-Vico; María Fernández-Hevia; Aida Suárez-Sánchez; Carmen García-Gutiérrez; Luka Mihic-Góngora; Daniel Fernández-Martínez; José Antonio Álvarez-Pérez; Jorge Luis Otero-Díez; José Electo Granero-Trancón; Luis Joaquín García-Flórez Journal: Ann Surg Oncol Date: 2021-06-04 Impact factor: 5.344
Authors: F Bianco; S De Franciscis; A Belli; A Falato; R Fusco; D F Altomare; A Amato; C R Asteria; A Avallone; G A Binda; L Boccia; P Buzzo; M Carvello; C Coco; P Delrio; P De Nardi; M Di Lena; A Failla; F La Torre; M La Torre; M Lemma; P Luffarelli; G Manca; I Maretto; F Marino; A Muratore; A Pascariello; S Pucciarelli; D Rega; V Ripetti; G Rizzo; A Serventi; A Spinelli; F Tatangelo; E D L Urso; G M Romano Journal: Tech Coloproctol Date: 2017-02-13 Impact factor: 3.781
Authors: Noura Alhassan; Mei Yang; Nathalie Wong-Chong; A Sender Liberman; Patrick Charlebois; Barry Stein; Gerald M Fried; Lawrence Lee Journal: Surg Endosc Date: 2018-09-12 Impact factor: 4.584