| Literature DB >> 27022736 |
Zhidan Mei1, Li Zhou2, Youhua Zhu1, Kejia Jie1, Daqing Fan1, Jian Chen1, Xiguo Liu1, Liang Jiang1, Qike Jia1, Wei Li3.
Abstract
Interleukin-22 (IL-22) is an inflammatory cytokine mainly produced by activated Th17 and Th22 cells. The data presented here demonstrate that IL-22 induced the migration and invasion of papillary thyroid cancer (PTC) cells. MicroRNA expression analysis and functional studies indicated that IL-22-mediated migration and invasion is positively regulated by miR-595. Further mechanistic studies revealed that sex-determining region Y-box 17 (Sox17) is directly targeted by miR-595. We then demonstrated that IL-22 regulated migration and invasion of PTC cells via inhibiting Sox17 expression. Interestingly, in PTC cell lines and PTC tissues, expression of IL-22 and miR-595 was upregulated and Sox17 downregulated compared with normal thyroid, and their expression levels were closely correlated. Taken together, this present study suggests that IL-22 stimulation enhances the migration and invasion of PTC cells by regulating miR-595 and its target Sox17.Entities:
Keywords: Interleukin-22; Invasion; Migration; Papillary thyroid cancer; Sox17; miR-595
Mesh：
Substances：
Year: 2016 PMID： 27022736 DOI： 10.1007/s13277-016-5030-1
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283