Hui Pang1, Bing Han2, Qiang Fu2, Zhenkun Zong3. 1. Department of Cardiovascular Medicine, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu, China. Electronic address: phui81@126.com. 2. Department of Cardiovascular Medicine, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu, China. 3. Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
Abstract
PURPOSE: We aimed to investigate the association between stroke morbidity and different stratifications of classic risk factors, such as increasing age, body mass index (BMI), blood lipids, and blood glucose, in hypertensive patients with high homocysteine levels. METHODS: A cross-sectional study of 2258 patients with primary hypertension were enrolled in this study, including 871 stroke cases (62.89%) in 1385 hypertensive patients without hyperhomocysteinemia (HHcy) and 647 (74.11%) stroke cases in 873 hypertensive patients with HHcy. Basic information of patients were collected, including age, sex, height, weight, smoking, alcohol consumption, and disease history. Blood chemical assays were performed to determine the levels of glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), total cholesterol, and homocysteine. Subsequently, comparison of stroke morbidity between the 2 groups was performed after the stratification of risk factors. Moreover, the correlation between the stroke morbidity and the risk factors was analyzed using a trend test in patients with H-type hypertension. Univariate and multivariate logistic regression analyses were used to evaluate the association between baseline factors and prevalence of stroke in H-type hypertensive patients. FINDINGS: After the stratification of risk factors, a statistical difference was noted in age (range, 45-74 yrs), glucose ranges (<6.1 and ≥7.0 mmol/L), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), non-HDL-C, and triglyceride level of <200 mg/dL (P<0.05) in the H-type hypertension group compared with those in non-H-type hypertension group. Gradual elevation of stroke morbidity was identified with the increase of fasting glucose, SBP, and DBP. In multivariate logistic regression analysis, only higher SBP, DBP, fasting glucose level, homocysteine, and history of diabetes mellitus were the independent predictors for the stroke morbidity. IMPLICATIONS: Comprehensive evaluation and strict management of multiple risk factors have become increasingly important in the alleviation of stroke morbidity for H-type hypertensive patients because these patients were more sensitive to the classic risk factors.
PURPOSE: We aimed to investigate the association between stroke morbidity and different stratifications of classic risk factors, such as increasing age, body mass index (BMI), blood lipids, and blood glucose, in hypertensivepatients with high homocysteine levels. METHODS: A cross-sectional study of 2258 patients with primary hypertension were enrolled in this study, including 871 stroke cases (62.89%) in 1385 hypertensivepatients without hyperhomocysteinemia (HHcy) and 647 (74.11%) stroke cases in 873 hypertensivepatients with HHcy. Basic information of patients were collected, including age, sex, height, weight, smoking, alcohol consumption, and disease history. Blood chemical assays were performed to determine the levels of glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), total cholesterol, and homocysteine. Subsequently, comparison of stroke morbidity between the 2 groups was performed after the stratification of risk factors. Moreover, the correlation between the stroke morbidity and the risk factors was analyzed using a trend test in patients with H-type hypertension. Univariate and multivariate logistic regression analyses were used to evaluate the association between baseline factors and prevalence of stroke in H-type hypertensivepatients. FINDINGS: After the stratification of risk factors, a statistical difference was noted in age (range, 45-74 yrs), glucose ranges (<6.1 and ≥7.0 mmol/L), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), non-HDL-C, and triglyceride level of <200 mg/dL (P<0.05) in the H-type hypertension group compared with those in non-H-type hypertension group. Gradual elevation of stroke morbidity was identified with the increase of fasting glucose, SBP, and DBP. In multivariate logistic regression analysis, only higher SBP, DBP, fasting glucose level, homocysteine, and history of diabetes mellitus were the independent predictors for the stroke morbidity. IMPLICATIONS: Comprehensive evaluation and strict management of multiple risk factors have become increasingly important in the alleviation of stroke morbidity for H-type hypertensivepatients because these patients were more sensitive to the classic risk factors.
Authors: John P Kirwan; Steven K Malin; Amanda R Scelsi; Emily L Kullman; Sankar D Navaneethan; Mangesh R Pagadala; Jacob M Haus; Julianne Filion; Jean-Philippe Godin; Sunil Kochhar; Alastair B Ross Journal: J Nutr Date: 2016-10-19 Impact factor: 4.798
Authors: Tan Li; Jiajia Zhu; Qi Fang; Xiaoyu Duan; Mingzhi Zhang; Shanshan Diao; Yun Zhou; Si Yang; Yan Kong; Xiuying Cai Journal: Biomed Res Int Date: 2018-09-09 Impact factor: 3.411
Authors: Tan Li; Xueyun Liu; Shanshan Diao; Yan Kong; Xiaoyu Duan; Si Yang; Sanjiao Liu; Qi Fang; Xiuying Cai Journal: Biomed Res Int Date: 2020-02-07 Impact factor: 3.411