Literature DB >> 2702114

Nifedipine, verapamil and cyclosporin A pharmacokinetics in children.

M R Ogborn1, J F Crocker, P C Grimm.   

Abstract

We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

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Year:  1989        PMID： 2702114     DOI： 10.1007/BF00858540

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  14 in total

1.  Does nifedipine ameliorate cyclosporin A nephrotoxicity?

Authors:  J Feehally; J Walls; N Mistry; T Horsburgh; J Taylor; P S Veitch; P R Bell
Journal:  Br Med J (Clin Res Ed)       Date:  1987-08-01

2.  Cyclosporine A: a clinical evaluation of drug interactions.

Authors:  I Cockburn
Journal:  Transplant Proc       Date:  1986-12       Impact factor: 1.066

3.  Verapamil inhibits cyclosporin metabolism.

Authors:  A Lindholm; S Henricsson
Journal:  Lancet       Date:  1987-05-30       Impact factor: 79.321

4.  Diltiazem and economic use of cyclosporin.

Authors:  H H Neumayer; K Wagner
Journal:  Lancet       Date:  1986-08-30       Impact factor: 79.321

5.  The first pass metabolism of nifedipine in man.

Authors:  D G Waller; A G Renwick; B S Gruchy; C F George
Journal:  Br J Clin Pharmacol       Date:  1984-12       Impact factor: 4.335

6.  Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.

Authors:  R A Robson; J O Miners; D J Birkett
Journal:  Br J Clin Pharmacol       Date:  1988-03       Impact factor: 4.335

7.  The effect of verapamil on cellular uptake, organ distribution, and pharmacology of cyclosporine.

Authors:  M A McMillen; W K Baumgarten; H C Schaefer; E Mitchnick; M Fuortes; M J Holman; R J Tesi
Journal:  Transplantation       Date:  1987-09       Impact factor: 4.939

8.  Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil.

Authors:  K W Renton
Journal:  Biochem Pharmacol       Date:  1985-07-15       Impact factor: 5.858

9.  The effect of verapamil in reducing the severity of acute tubular necrosis in canine renal autotransplants.

Authors:  E H Agatstein; J H Farrer; L M Kaplan; R F Randazzo; R J Glassock; J J Kaufman
Journal:  Transplantation       Date:  1987-09       Impact factor: 4.939

10.  Cyclosporin A in paediatric kidney transplantation.

Authors:  G Offner; P F Hoyer; J Brodehl; R Pichlmayr
Journal:  Pediatr Nephrol       Date:  1987-04       Impact factor: 3.714
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  2 in total

1.  The interaction of the calcium channel blockers verapamil and nifedipine with cyclosporin A in pediatric renal transplant patients.

Authors:  J F Crocker; K W Renton; T L LeVatte; D H McLellan
Journal:  Pediatr Nephrol       Date:  1994-08       Impact factor: 3.714

Review 2.  Pharmacological management of hypertension in paediatric patients. A comprehensive review of the efficacy, safety and dosage guidelines of the available agents.

Authors:  K Miller
Journal:  Drugs       Date:  1994-12       Impact factor: 9.546
  2 in total

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