Literature DB >> 27020685

Synthetic approaches to the 2014 new drugs.

Andrew C Flick1, Hong X Ding2, Carolyn A Leverett3, Robert E Kyne4, Kevin K-C Liu5, Sarah J Fink6, Christopher J O'Donnell7.   

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords:  Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents

Mesh：

Year:  2016        PMID： 27020685     DOI： 10.1016/j.bmc.2016.03.004

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Pd-Catalyzed Synthesis of Piperazine Scaffolds Under Aerobic and Solvent-Free Conditions.

Authors:  Sean W Reilly; Robert H Mach
Journal:  Org Lett       Date:  2016-10-13       Impact factor: 6.005

2.  Alkylation of Sulfonamides with Trichloroacetimidates under Thermal Conditions.

Authors:  Daniel R Wallach; John D Chisholm
Journal:  J Org Chem       Date:  2016-08-10       Impact factor: 4.354

Review 3.  A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds.

Authors:  Tejas M Dhameliya; Hiren A Donga; Punit V Vaghela; Bhoomi G Panchal; Dipen K Sureja; Kunjan B Bodiwala; Mahesh T Chhabria
Journal:  RSC Adv       Date:  2020-09-03       Impact factor: 4.036

4.  Engineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration.

Authors:  Ran Zuo; Yi Zhang; Chao Jiang; John C Hackett; Rosemary Loria; Steven D Bruner; Yousong Ding
Journal:  Sci Rep       Date:  2017-04-12       Impact factor: 4.379

5.  Development of a Method for Rapid Determination of Morpholine in Juices and Drugs by Gas Chromatography-Mass Spectrometry.

Authors:  Mengsi Cao; Pingping Zhang; Yanru Feng; Huayin Zhang; Huaijiao Zhu; Kaoqi Lian; Weijun Kang
Journal:  J Anal Methods Chem       Date:  2018-04-26       Impact factor: 2.193

6.  (2Z)-3-Hydroxy-3-(4-R-Phenyl)-Prop-2-Enedithioic Acids as New Antituberculosis Compounds.

Authors:  Gustavo Pretelín-Castillo; Mayra Silva Miranda; Clara Espitia; Rosa María Chávez-Santos; Abel Suárez-Castro; Luis Chacón-García; Rodrigo Aguayo-Ortiz; Roberto Martinez
Journal:  Infect Drug Resist       Date:  2021-10-20       Impact factor: 4.003

7.  Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib.

Authors:  Zhaohang Chen; Shuai Wang; Kangjie Liu; Rui Zhang; Qiaoying Li; Weiguang Bian; Renzhong Qiao; Chao Li
Journal:  ACS Omega       Date:  2022-02-11

8.  Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic β cells: in vitro and in vivo studies.

Authors:  Pan Liu; Zhengdong Zhang; Jinwu Wang; Xiao Zhang; Xiaoping Yu; Yao Li
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

Review 9.  Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases.

Authors:  Hollis D Showalter
Journal:  Molecules       Date:  2020-09-10       Impact factor: 4.411
  9 in total

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