Peng-Sheng Yi1, Ming Zhang, Ming-Qing Xu. 1. Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. xumingqing0018@163.com.
Abstract
BACKGROUND: Liver regeneration is a complex process. microRNAs (miRNAs) are short, single-stranded RNAs that modify gene expression at the post-transcriptional level. Recent investigations have revealed that miRNAs are closely linked to liver regeneration. DATA SOURCES: All included studies were obtained from PubMed, Embase, the ScienceDirect databases and Web of Science, with no limitation on publication year. Only studies published in English were considered. RESULTS: We grouped studies that involved miRNA and liver regeneration into two groups: miRNAs as promoters and as inhibitors of liver regeneration. We summarized the relevant miRNAs separately from the related pathways. CONCLUSIONS: Blocking or stimulating the pathways of miRNAs in liver regeneration may be novel therapeutic strategies in future regeneration-related liver managements. We may discover additional chemotherapy targets of miRNA.
BACKGROUND: Liver regeneration is a complex process. microRNAs (miRNAs) are short, single-stranded RNAs that modify gene expression at the post-transcriptional level. Recent investigations have revealed that miRNAs are closely linked to liver regeneration. DATA SOURCES: All included studies were obtained from PubMed, Embase, the ScienceDirect databases and Web of Science, with no limitation on publication year. Only studies published in English were considered. RESULTS: We grouped studies that involved miRNA and liver regeneration into two groups: miRNAs as promoters and as inhibitors of liver regeneration. We summarized the relevant miRNAs separately from the related pathways. CONCLUSIONS: Blocking or stimulating the pathways of miRNAs in liver regeneration may be novel therapeutic strategies in future regeneration-related liver managements. We may discover additional chemotherapy targets of miRNA.
Authors: Robert Mukiibi; Dayle Johnston; Michael Vinsky; Carolyn Fitzsimmons; Paul Stothard; Sinéad M Waters; Changxi Li Journal: Sci Rep Date: 2020-11-09 Impact factor: 4.379
Authors: Yana V Kiseleva; Sevak Z Antonyan; Tatyana S Zharikova; Kirill A Tupikin; Dmitry V Kalinin; Yuri O Zharikov Journal: World J Hepatol Date: 2021-03-27